25957-11-3Relevant academic research and scientific papers
Efficient one-pot synthesis of 7-azacoumarins by knoevenagel reaction using water as reaction medium
Brufola, Gianluca,Fringuelli, Francesco,Piermatti, Oriana,Pizzo, Ferdinando
, p. 1715 - 1721 (1997)
3-Substituted 5-hydroxymethyl-8-methyl-7-azacoumarins were prepared by a Knoevenagel reaction of pyridoxal hydrochloride with acetonitriles in a one-pot procedure in a water-only medium. The reactions occurred in heterogeneous phase with much better yields than those obtained in a homogeneous alcoholic medium.
