Efficient one-pot synthesis of 7-azacoumarins by knoevenagel reaction using water as reaction medium

Article abstract of DOI:10.3987/com-97-7857

3-Substituted 5-hydroxymethyl-8-methyl-7-azacoumarins were prepared by a Knoevenagel reaction of pyridoxal hydrochloride with acetonitriles in a one-pot procedure in a water-only medium. The reactions occurred in heterogeneous phase with much better yields than those obtained in a homogeneous alcoholic medium.