25965-81-5

Basic information

• Product Name: Pyridinium, 1-(2-propenyl)-, chloride
• Synonyms: Pyridinium, 1-(2-propenyl)-, chloride;1-(2-propenyl)-pyridiniu chloride;1-(2-propenyl)pyridinium chloride
• CAS NO: 25965-81-5
• Molecular Formula: C8H10 N . Cl
• Molecular Weight: 155.63
• EINECS: 412-740-5
• Mol File: 25965-81-5.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Pyridinium, 1-(2-propenyl)-, chloride(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridinium, 1-(2-propenyl)-, chloride(25965-81-5)
• EPA Substance Registry System: Pyridinium, 1-(2-propenyl)-, chloride(25965-81-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 24-37
• Hazardous Substances Data: 25965-81-5(Hazardous Substances Data)

Usage

General Description

Pyridinium, 1-(2-propenyl)-, chloride is a chemical compound with the molecular formula C8H11ClN. It is a quaternary ammonium salt that is commonly used as a phase-transfer catalyst in organic synthesis. Pyridinium, 1-(2-propenyl)-, chloride is a volatile and highly flammable liquid that is soluble in water and organic solvents. It is also known by its other names such as 2-(chloromethyl)pyridine and 2-chloromethylpyridine. This chemical is used in various industrial applications, including pharmaceuticals, agrochemicals, and as an intermediate in the synthesis of other organic compounds. It is important to handle and store this compound with proper safety measures due to its flammability and toxic nature.

Upstream product

• 110-86-1 pyridine 
• 107-05-1 3-chloroprop-1-ene 

Relevant articles and documents

Versatile Method for the Simultaneous Synthesis of Two Ionic Liquids, Otherwise Difficult to Obtain, with High Atom Economy

A new synthetic approach and full spectral (NMR, IR, MS) and ion chromatographic characterization (IC) of nitrogen-based ionic liquids bearing allyl- or ethyl- substituent and triflate, tosylate, methyl sulfate or methanesulfonate anion has been presented. On a sample of 16 new ionic liquids, the versatility of the anion exchange method has been proven. In the metathesis reactions that have been carried out, the halide anion was exchanged in ionic liquid with an alkyl sulfonate based anion using alkylating agents. The results obtained using ion chromatographic analysis on the newly synthesized compounds have been discussed. Also, the utilization of a gaseous methyl halide by-product, obtained in the metathesis reaction and otherwise difficult to synthesize, has been presented. This approach ensured high atom economy of the overall process, which makes the proposed methodology sustainable and eco-friendly.

Synthesis and evaluation of influenza A viral neuraminidase candidate inhibitors based on a bicyclo[3.1.0]hexane scaffold

This manuscript describes a novel class of derivatives based on a bicyclo[3.1.0]hexane scaffold, proposed as mimics of sialic acid in a distorted boat conformation that is on the catalytic pathway of neuraminidases (sialidases). A general synthetic route for these constrained-ring molecules was developed using a photochemical reaction followed by a Johnson-Corey-Chaykovsky cyclopropanation. Functionalization with the goal of occupying the 150-cavity was also exploited. Inhibition assays demonstrated low micromolar inhibition against both group-1 (H5N1) and group-2 (H9N2) influenza neuraminidase subtypes, indicating good affinity for the alpha and beta sialic acid mimics and 150-cavity-targeted derivatives. These results provide a validation of a bicyclo[3.1.0]hexane scaffold as a mimic of a distorted sialic acid bound in the neuraminidase active site during catalysis.