259675-77-9

Basic information

• Product Name: Pyridine, 2,3,4,6-tetrafluoro-5-(trimethylsilyl)-
• Synonyms: 2,3,4,6-Tetrafluoro-5-trimethylsilylpyridine;Pyridine,2,3,4,6-tetrafluoro-5-(trimethylsilyl)
• CAS NO: 259675-77-9
• Molecular Formula: C8H9F4NSi
• Molecular Weight: 223.24300
• Mol File: 259675-77-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Pyridine, 2,3,4,6-tetrafluoro-5-(trimethylsilyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Pyridine, 2,3,4,6-tetrafluoro-5-(trimethylsilyl)-(259675-77-9)
• EPA Substance Registry System: Pyridine, 2,3,4,6-tetrafluoro-5-(trimethylsilyl)-(259675-77-9)

Safety Data

• Hazardous Substances Data: 259675-77-9(Hazardous Substances Data)

Upstream product

• 109-72-8 n-butyllithium 
• 75-77-4 chloro-trimethyl-silane 
• 3512-13-8 2,3,4,6-tetrafluoropyridine 

Relevant articles and documents

Preparation and reactions of 2,3,4,6-tetrafluoropyridine and its derivatives

A reliable route to 2,3,4,6-tetrafluoropyridine has been established starting from the readily available 3,5-dichlorotrifluoropyridine by halogen exchange under controlled conditions to give 3-chlorotetrafluoropyridine and its subsequent hydrodechlorination using hydrogen over palladium on alumina at 250-270°C. The formation and reactions of the 3-lithio derivative have been studied with the aim of obtaining 3,4-disubstituted trifluoropyridines. Routes to such materials have been developed and their conversion to deazapurine derivatives as potential substrates for the generation of anti-sense nucleosides are reported.