25968-13-2Relevant academic research and scientific papers
6-Methoxy-N-methyl-1,2,3,4-tetrahydro-β-carboline from evodiae fructus
Yu, Li-Li,Ho, Li-Kang,Liao, Jyh-Fei,Chen, Chieh-Fu
, p. 471 - 472 (1997)
A receptor binding assay directed separation has led to the identification of a minor alkaloid 6-methoxy-N-methyl-1,2, 3,4-tetrahydro-β-carboline (1) from the Chinese herbal drug Evodiae Fructus [EF, the dried, unripe fruit of Evodia rutaecarpa Look. f. et Thomas (Rutaceae)]. The structure of compound 1 was elucidated by means of spectroscopic methods and a comparison with synthetic materials, Compound 1 interacted with 5-HT(1A) and 5-HT2 receptors with a moderate K(i) value of 78 and 1.2 μM, respectively. Compound 1 is found in EF and the genus Evodiae for the first time.
