20315-68-8

Basic information

• Product Name: 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE
• Synonyms: 6-METHOXY-2,3,4,9-TETRAHYDRO-1H-BETA-CARBOLINE;6-METHOXY-1,2,3,4-TETRAHYDRO-9 H-PYRIDO[3,4-B]INDOLE;6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE;2,3,4,9-tetrahydro-6-methoxy-1h-pyrido(3,4-b)indole;4-b)indole,2,3,4,9-tetrahydro-6-methoxy-1h-pyrido(;6-meothbc;6-methoxytetrahydro-beta-carboline;6-methoxytryptoline
• CAS NO: 20315-68-8
• Molecular Formula: C₁₂H₁₄N₂O
• Molecular Weight: 202.25
• Mol File: 20315-68-8.mol
• Article Data: 18

Chemical Properties

• Melting Point: 219-222 °C(lit.)
• Boiling Point: 388.6 °C at 760 mmHg
• Flash Point: 188.8 °C
• Appearance: /
• Density: 1.198 g/cm³
• Vapor Pressure: 3.03E-06mmHg at 25°C
• Refractive Index: 1.639
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• CAS DataBase Reference: 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE(20315-68-8)
• EPA Substance Registry System: 6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE(20315-68-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: UV0725000
• HazardClass: IRRITANT
• Hazardous Substances Data: 20315-68-8(Hazardous Substances Data)

Usage

Uses

6-Methoxy-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole is a stain/dye. Dyes and metabolites.

InChI:InChI=1/C12H14N2O/c1-15-8-2-3-11-10(6-8)9-4-5-13-7-12(9)14-11/h2-3,6,13-14H,4-5,7H2,1H3

Upstream product

• 19501-58-7 4-methoxyphenylhydrazine hydrochloride 
• 98977-36-7 3-oxo-piperidine-1-carboxylic acid tert-butyl ester 
• 1029578-08-2 6-methoxy-1,3,4,9-tetrahydropyrido[3,4-b]indole-2-carboxylic acid tert-butyl ester 
• 608-07-1 2-(5-methoxyindol-3-yl)ethylamine 
• 66-83-1 5-methoxytryptamine hydrochloride 
• 17952-63-5 6-methoxy-2,3,4,9-tetrahydro-1H-β-carboline-1-carboxylic acid 
• 7212-59-1 4,9-dihydro-6-methoxy-3H-pyrido[3,4-b]indole 
• 298-12-4 Glyoxilic acid 
• 50-00-0 formaldehyd 
• 17952-87-3 6-methoxy-2,3,4,9-tetrahydro-β-carbolin-1-one 

Downstream Products

• 25968-13-2 6-methoxy-2,9-dimethyl-2,3,4,9-tetrahydro-1H-β-carboline 
• 58982-28-8 6-Hydroxy-beta-Carboline 
• 777084-01-2 1-[bis[(2-aminoethyl)]aminosulfonyl]-4-(1,2,3,4-tetrahydro-9H-pyrido-6-methoxy[3,4-b]indol-2-methyl)benzene 
• 497183-01-4 2-benzenesulfonyl-6-methoxy-2,3,4,9-tetrahydro-1H-β-carboline 
• 240117-84-4 6-methoxy-2-(4-phenyl-butyl)-2,3,4,9-tetrahydro-1H-β-carboline 
• 107890-06-2 2-(2,6-Dimethoxy-benzyl)-6-methoxy-2,3,4,9-tetrahydro-1H-β-carboline 
• 107889-89-4 6-Methoxy-2-(2-pyridin-4-yl-ethyl)-2,3,4,9-tetrahydro-1H-β-carboline 

Relevant articles and documents

Catalytic Enantioselective Synthesis of Spirooxindoles by Oxidative Rearrangement of Indoles

Oxidative rearrangement of indoles to access oxindoles has been used as a key step in complex molecule synthesis. We report a catalytic enantioselective variant of this transformation by chiral phosphoric acid catalysis, providing rapid access to a range of enantioenriched spirooxindoles. The high enantioselectivity is controlled by dynamic kinetic resolution.

Aromatic heterocyclic derivative and application thereof in medicine

The invention provides aromatic heterocyclic derivatives or stereoisomers, tautomers, nitrogen oxides, solvates, metabolites, pharmaceutically acceptable salts or prodrugs thereof, which are used for treating Alzheimer's disease. The invention also discloses pharmaceutical compositions containing the compounds and a method for treating Alzheimer's disease by using the compounds or the pharmaceutical compositions provided by the invention.

TETRAHYDROBENZOFURO[2,3-C]PYRIDINE AND BETA-CARBOLINE COMPOUNDS FOR THE TREATMENT, ALLEVIATION OR PREVENTION OF DISORDERS ASSOCIATED WITH TAU AGGREGATES

The present invention relates to novel compounds of formula (I) that can be employed in the treatment, alleviation or prevention of a group of disorders and abnormalities associated with Tau (Tubulin associated unit) protein aggregates including, but not limited to, Neurofibrillary Tangles (NFTs), such as Alzheimer's disease (AD).