259684-24-7Relevant academic research and scientific papers
A β-galactoside phosphoramide mustard prodrug for use in conjunction with gene-directed enzyme prodrug therapy
Ghosh, Ajit K.,Khan, Saeed,Farquhar, David
, p. 2527 - 2528 (1999)
4-(β-D-Galactopyranosyl)benzyl N,N,N',N'-tetrakis(2- chloroethyl)phosphorodiamidate 1 was facilely biotransformed to the alkylating antitumor agent, N,N,N',N'-tetrakis(2-chloroethyl) phosphorodiamidic acid, 4, when incubated with E. coli β-galactosidase, and therefore has potential for use in conjunction with gene-directed enzyme prodrug therapy.
