259729-26-5Relevant academic research and scientific papers
Chloroform is not solvent but activator for cobalt complex catalyst of enantioselective borohydride reduction
Kokura, Ai,Tanaka, Saiko,Teraoka, Haruna,Shibahrara, Atsushi,Ikeno, Taketo,Nagata, Takushi,Yamada, Tohru
, p. 26 - 27 (2007/10/03)
For the enantioselective borohydride reduction of carbonyl compounds catalyzed by the optically active ketoiminatocobalt complexes, chloroform has been employed as a unique solvent for achieving a high enantioselectivity, whereas it was found that a catal
Enantioselective borohydride reduction catalyzed by optically active cobalt complexes
Yamada, Tohru,Nagata, Takushi,Sugi, Kiyoaki D.,Yorozu, Kiyotaka,Ikeno, Taketo,Ohtsuka, Yuhki,Miyazaki, Daichi,Mukaiyama, Teruaki
, p. 4485 - 4509 (2007/10/03)
The highly enantioselective borohydride reduction of aromatic ketones or imines to the corresponding alcohols was developed in the presence of a catalytic amount of an optically active cobalt(II) complex catalyst. This enantioselective reduction is carried out using a precisely premodified borohydride with alcohols such as tetrahydrofurfuryl alcohol, ethanol and methanol. High optical yields are obtained by choosing the appropriate alcohol as modifiers and a suitable β-ketoiminato ligand of the catalyst. The enantioselective borohydride reduction has been successfully applied to the preparation of optically active 1,3-diols, the stereoselective reduction of diacylferrocenes, and dynamic and/or kinetic resolution of 1,3-dicarbonyl compounds.
Enantioselective borohydride reduction of N-diphenylphosphinyl imines using optically active cobalt(II) complex catalysts
Sugi, Kiyoaki D.,Nagata, Takushi,Yamada, Tohru,Mukaiyama, Teruaki
, p. 493 - 494 (2007/10/03)
The enantioselective borohydride reduction using optically active cobalt(II) complex catalysts was successfully applied to various aryl N-diphenylphosphinyl imines, and the corresponding reduced products were obtained in good yields with high enantiomeric excesses (up to 99% ee). The optically active primary amines were obtained by the successive hydrolysis under mild conditions.
