314019-11-9

Usage

Uses

Used in Pharmaceutical Industry:
(S)-6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE is used as a building block for the synthesis of various biologically active molecules and pharmaceutical drugs, contributing to the development of novel therapeutic agents.
Used as a Precursor in Organic Compound Production:
(S)-6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE is used as a precursor in the production of various organic compounds, highlighting its importance in the chemical industry for creating a range of products.
Used in Neurological Disorder Treatment:
(S)-6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE is studied for its potential application in the treatment of neurological disorders, as it has been identified as a serotonin receptor agonist, which may play a role in managing such conditions.
Used in Research and Development:
(S)-6-METHOXY-1,2,3,4-TETRAHYDRONAPHTHALEN-1-AMINE is utilized in research and development for exploring its pharmacological properties and potential uses in medicine, further expanding its applications in the scientific community.

Upstream product

• 120342-64-5 1-azido-6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 1078-19-9 6-methoxy-3,4-dihydro-1(2H)-naphthalenone 
• 16821-32-2 6-methoxy-1,2,3,4-tetrahydronaphthalen-1-ol 
• 259729-26-5 (S)-N-(diphenylphosphinyl)-6-methoxy-1,2,3,4-tetrahydro-1-naphthylamine 
• 52373-02-1 6-methoxy-1-amino-1,2,3,4-tetrahydronaphthalene 
• 1730-48-9 6-methoxy-1,2,3,4-tetrahydronaphthalene 
• 536717-83-6 O-tert-butyldimethylsilyl-6-methoxy-1-tetralone oxime 
• 192461-82-8 N-(6-methoxy-1,2,3,4-tetrahydro-1-naphthylidene)-P,P-diphenylphosphinamide 

Downstream Products

• 39226-88-5 6-methoxy-1,2,3,4-tetrahydronaphthalene-1-ylamine hydrochloride 

Relevant academic research and scientific papers

PERIPHERAL ALKYL AND ALKENYL CHAINS EXTENDED BENZENE DERIVATIVES AND PHARMACEUTICAL COMPOSITION INCLUDING THE SAME

The compounds represented by Formula (I), which are peripheral alkyl and alkenyl chains extended benzene derivatives, are useful as dual autotaxin (ATX) / histone deacetylase (HD AC) inhibitors. These compounds may be included in a pharmaceutical composition along with a pharmaceutically acceptable carrier, and be used in a therapeutically effective amount for prophylaxis or treatment of various diseases and disorders.

COMPOSITIONS AND METHODS FOR CYCLOFRUCTANS AS SEPARATION AGENTS

The present invention relates to derivatized cyclofructan compounds, compositions comprising derivatized cyclofructan compounds, and methods of using compositions comprising derivatized cyclofructan compounds for chromatographic separations of chemical species, including enantiomers. Said compositions may comprise a solid support and/or polymers comprising derivatized cyclofructan compounds.

SUBSTITUTED ARYLAMINE COMPOUNDS AND THEIR USE AS 5-HT6 MODULATORS

The invention relates to 5-HT6 receptor antagonists. Novel arylamine compounds having the formula: (see formula I) and pharmaceutically acceptable salts and/or esters thereof, wherein - n is 0, 1, 2, 3, or 4; - A, when present is a lower alkyl

Facile rearrangement of O-silylated oximes on reduction with boron trifluoride/borane

Aromatic O-triisopropylsilyl ketoximes were efficiently rearranged to cyclic and acyclic aniline derivatives on reduction with BF3- ethearate /borane. The bulk of the substituents on the silicon atom, the size of the aliphatic ring, and the presence of alkoxy substituents on the aryl group all play an important role in the aniline.

Substituted aryl 1,4-pyrazine derivatives

Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.

Enantioselective borohydride reduction of N-diphenylphosphinyl imines using optically active cobalt(II) complex catalysts

The enantioselective borohydride reduction using optically active cobalt(II) complex catalysts was successfully applied to various aryl N-diphenylphosphinyl imines, and the corresponding reduced products were obtained in good yields with high enantiomeric excesses (up to 99% ee). The optically active primary amines were obtained by the successive hydrolysis under mild conditions.

Selective Conversion of Benzylic C-H Bonds to an Amine Function by Oxidative Nucleophilic Substitution

The benzylic proton of alkylarenes 1 was replaced by an azido group in one step by reaction with trimethylsilyl azide or hydrazoic acid in chloroform in the presence of 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ).The 1-arylalkyl azides 2 were reduced to amines 3, which were characterized as their hydrochlorides 4.