259729-93-6Relevant academic research and scientific papers
A new and direct asymmetric synthesis of a hindered chiral amine via a novel sulfinate ketimine derived from N-tosyl-1,2,3-oxathiazolidme-2-oxide: Practical asymmetric synthesis of (R)-sibutramine
Han, Zhengxu,Krishnamurthy, Dhileepkumar,Senanayake, Chris H.
, p. 327 - 333 (2012/12/22)
A novel and direct approach for the asymmetric synthesis of (R)-sibutramine via chiral amine 5 using N-tosyl-1,2,3-oxathiazolidine-2-oxide (13) as a recyclable chiral auxiliary is described. Chiral sulfinate imine 16e was obtained by treatment of 13e with
A method of manufacturing an amine stereoisomerically
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Page/Page column 53-55, (2010/02/12)
This invention provides intermediates useful in a method of preparing amine stereoisomers. It also provides a method of preparing sulfoxide and sulfinylamine stereoisomers using certain of the intermediates.
