259745-55-6Relevant academic research and scientific papers
Combinatorial chemistry. Use of an intramolecular ruthenium catalyzed olefin/alkyne metathesis reaction in tandem with a Diels-Alder cycloaddition reaction to construct functionalized hexahydroisoindoles
Heerding, Dirk A.,Takata, Dennis T.,Kwon, Chet,Huffman, William F.,Samanen, James
, p. 6815 - 6818 (2007/10/03)
We show here the first example of a ruthenium catalyzed ene-yne metathesis reaction. In tandem with a Diels Alder cycloaddition reaction to efficiently form highly substituted hexahydroisoindole ring systems on Wang resin. This approach was used to prepare a 4200 membered combinatorial library.
