259752-50-6

Basic information

• Product Name: (2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-[(methylsulfonyl)oxy]-4-phenylbutyl acetate
• Synonyms: (2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-[(methylsulfonyl)oxy]-4-phenylbutyl acetate
• CAS NO: 259752-50-6
• Molecular Weight: 401.481
• Mol File: 259752-50-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-[(methylsulfonyl)oxy]-4-phenylbutyl acetate(CAS DataBase Reference)
• NIST Chemistry Reference: (2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-[(methylsulfonyl)oxy]-4-phenylbutyl acetate(259752-50-6)
• EPA Substance Registry System: (2S,3S)-3-[(tert-butoxycarbonyl)amino]-2-[(methylsulfonyl)oxy]-4-phenylbutyl acetate(259752-50-6)

Safety Data

• Hazardous Substances Data: 259752-50-6(Hazardous Substances Data)

Upstream product

• 1393955-00-4 (3S)-3-([(1,1-dimethylethyl)oxy]carbonylamino)-1-(methylsulfanyl)-2-oxo-4-phenylbutyl ethanoate 
• 51987-73-6 (S)-2-tert-butoxycarbonylamino-3-phenyl-propionic acid methyl ester 
• 1393955-13-9 (3S)-3-([(1,1-dimethylethyl)oxy]carbonylamino)-2-hydroxy-4-phenylbutyl ethanoate 
• 124-63-0 methanesulfonyl chloride 
• 180713-67-1 (2S, 3S)-1-acetoxy-3-(t-butoxycarbonylamino)-2-hydroxy-4-phenylbutane 

Downstream Products

• 98760-08-8 (2R,3S)-3-[N-(tert-butyloxycarbonyl)amino]-1,2-epoxy-4-phenylbutane 

Relevant articles and documents

PROCESS FOR REDUCTION OF ALPHA-ACYLOXY SULFIDE DERIVATIVES

The present invention provides an efficient and scalable process to prepare the compound of formula 4 by reduction of the corresponding α-acyloxy sulfides.

Process for the preparation of (2r,3s)-3-amino-1,2-oxirane

A process for producing (2R,3S)-3-amino-4-phenylbutane-1,2-epoxide compounds which comprises treating a (2S,3S)-3-amino-1-halo-2-hydroxy-4-phenylbutane compound or a (2S,3S)-3-amino-4-phenylbutane-1,2-epoxide with a carboxylic acid quaternary ammonium salt or a carboxylic acid metal salt a quaternary ammonium salt and a quaternary ammonium salt, to give a (2S,3S)-1-acyloxy-3-amino-2-hydroxy-4-phenylbutane compound, further treating the same with a sulfonic acid halide in the presence of an organic base to give a (2S,3S)-1-acyloxy-3-amino-2-sulfonyloxy-4-phenylbutane compound, furthermore treating said compound with an inorganic base.