259793-88-9

Usage

Uses

Used in Pharmaceutical Industry:
6-bromo-3-hydroxypyrazine-2-carboxamide is used as a key intermediate in the synthesis of Favipiravir for the treatment of advanced Ebola virus infection. Favipiravir has demonstrated its effectiveness in suppressing the replication of Zaire Ebola virus and preventing lethal outcomes in small animal models. The compound's role in the development of Favipiravir positions it as a potential candidate for the treatment of Ebola hemorrhagic fever, offering hope for patients suffering from this severe and often fatal disease.

Upstream product

• 27825-20-3 3-hydroxypyrazine-2-carboxylic acid methyl ester 
• 21874-61-3 3-hydroxy-6-bromopyrazine-2-carboxylic acid methyl ester 
• 55321-99-8 3-oxo-3,4-dihydropyrazine-2-carboxamide 

Relevant academic research and scientific papers

Preparation method of favipiravir

The invention relates to the technical field of biological medicines, in particular to a preparation method of favipiravir, which comprises the following steps of: stirring 3-hydroxy pyrazine-2-formamide and a fluorinating reagent in a solvent, and carrying out one-step reaction to obtain favipiravir. The preparation method of favipiravir provided by the invention is short and novel in route, mildin reaction condition, economical and effective, higher in yield than the existing preparation method, and suitable for large-scale industrial production.

6-bromo-3-hydroxy-2-pyrazine amide preparation method (by machine translation)

The invention belongs to the field of chemical synthesis, in particular relates to a 6-bromo-3-hydroxy-2-pyrazine amide preparation method, in order to 3-hydroxy-2-pyrazine carboxylic acid methyl ester as the starting material, into the first 6-bromo-3-hydroxy-2-pyrazine carboxylic acid methyl ester, after aminolysis, can be through simple operation, to a higher yield in the preparation of 6-bromo-3-hydroxy-2-pyrazine amide. The advantage of this invention lies in: the low price, market procurement convenient 3-hydroxy-2-pyrazine carboxylic acid methyl ester as a starting material, the process for the preparation of simple and easy, and the wide range of application of a solvent, the solvent is easy to remove, high yield, can be applied to the industrial production. (by machine translation)