259817-68-0

Upstream product

• 66572-56-3 2-bromoisonicotinic acid 
• 129077-93-6 (S)-(+)-3,4-dimethoxyphenylalanine ethyl ester hydrochloride 

Downstream Products

• 209261-98-3 acetic acid 3-(3,4-dimethoxy-phenyl)-2-{[2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-pyridine-4-carbonyl]-amino}-propyl ester 
• 209262-40-8 (2S)-1-acetoxy-3-(3,4-dimethoxyphenyl)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}propane 
• 209261-95-0 acetic acid 3-(3,4-dimethoxy-phenyl)-2-{[2-(1-oxo-4-pyrimidin-5-yl-1H-phthalazin-2-yl)-pyridine-4-carbonyl]-amino}-propyl ester 
• 209261-90-5 N-[2-(3,4-dimethoxy-phenyl)-1-hydroxymethyl-ethyl]-2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-isonicotinamide 
• 209261-87-0 N-[2-(3,4-dimethoxy-phenyl)-1-hydroxymethyl-ethyl]-2-(1-oxo-4-pyrimidin-5-yl-1H-phthalazin-2-yl)-isonicotinamide 
• 209262-39-5 (2S)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}-3-(3,4-dimethoxyphenyl)-1-propanol 
• 209262-38-4 (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol 

Relevant academic research and scientific papers

Synthesis and biological activities of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives as PDE4 inhibitors

A novel series of 1-pyridylisoquinoline and 1-pyridyldihydroisoquinoline derivatives has been prepared. These compounds showed potent PDE4 inhibitory activities and a broad margin between the Ki value of the rolipram binding affinity and the IC50 value of PDE4 inhibition. They also exhibited potent inhibitory activities toward LPS-induced TNF-α production in mice.