N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester

Base Information

• Chemical Name: N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester
• CAS No.: 259817-68-0
• Molecular Formula: C₁₉H₂₁BrN₂O₅
• Molecular Weight: 437.29
• Mol file: 259817-68-0.mol

Synonyms:N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester

Chemical Property of N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester

There total 1 articles about N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-bromoisonicotinic acid (66572-56-3) + (S)-(+)-3,4-dimethoxyphenylalanine ethyl ester hydrochloride (129077-93-6) → N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester (259817-68-0)

Guidance literature:

With benzotriazol-1-ol; dicyclohexyl-carbodiimide; In dichloromethane; at 25 ℃;

DOI:10.1016/S0960-894X(03)00438-4

Reference yield:

N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester (259817-68-0) → (2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol (209262-38-4)

Guidance literature:

With methanol; sodium tetrahydroborate; In tetrahydrofuran; Heating;

DOI:10.1016/S0960-894X(03)00438-4

Reference yield:

N-(2-bromoisonicotinoyl)-3-(3,4-dimethoxyphenyl)-L-alanine ethyl ester (259817-68-0) → N-[2-(3,4-dimethoxy-phenyl)-1-hydroxymethyl-ethyl]-2-[1-oxo-4-(pyridin-3-ylmethoxy)-1H-isoquinolin-2-yl]-isonicotinamide

Guidance literature:

Multi-step reaction with 2 steps

1: NaBH₄; MeOH / tetrahydrofuran / Heating

2: CuI; K₂CO₃ / dimethylformamide / 120 °C

With methanol; sodium tetrahydroborate; copper(l) iodide; potassium carbonate; In tetrahydrofuran; N,N-dimethyl-formamide; 2: Ullmann condensation;

DOI:10.1016/S0960-894X(03)00438-4

upstream raw materials:

2-bromoisonicotinic acid

(S)-(+)-3,4-dimethoxyphenylalanine ethyl ester hydrochloride

Downstream raw materials:

(2S)-2-(2-bromoisonicotinoylamino)-3-(3,4-dimethoxyphenyl)-1-propanol

(2S)-2-{2-[4-(3-pyridyl)phthalazin-1(2H)-on-2-yl]isonicotinoylamino}-3-(3,4-dimethoxyphenyl)-1-propanol

N-[2-(3,4-dimethoxy-phenyl)-1-hydroxymethyl-ethyl]-2-(1-oxo-4-pyrimidin-5-yl-1H-phthalazin-2-yl)-isonicotinamide

N-[2-(3,4-dimethoxy-phenyl)-1-hydroxymethyl-ethyl]-2-(1-oxo-4-pyridin-3-ylmethyl-1H-phthalazin-2-yl)-isonicotinamide