259822-92-9

Upstream product

• 199106-77-9 ethyl 2-hydroxy-4-oxo-2-phenylcyclohexanecarboxylate 
• 108124-04-5 4-oxo-2-phenyl-2-cyclohexene-1-carboxylic acid ethyl ester 
• 74-88-4 methyl iodide 

Downstream Products

• 30708-63-5 2-methyl-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one 
• 50715-87-2 2,6-dimethyl-5,6-dihydro-[1,1'-biphenyl]-3(4H)-one 

Relevant academic research and scientific papers

Studies on alkylation of Hagemann's ester and its derivatives with alkyl halides and Michael acceptors

Alkylation and Michael addition of ethyl 3-methyl-4-oxo-2-phenylcyclohex-2-enecarboxylate (1b) have been studied under basic conditions. Similar reactions with Hagemann's ester (1c) have been carried out using phase transfer catalysts as well as solid supports. The ratio of the C-1 to C-3 alkylated products have been determined. A probable explanation for the regioselectivity observed has been given.