259823-16-0

Upstream product

• 2140-76-3 2'-O-methyluridine 
• 61671-79-2 3',5'-di-O-acetyl-2'-O-methyluridine 
• 259823-15-9 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-O-methyl-β-D-ribo-furanosyl]-6-(1,2-diacetoxyethyl)-4-ethoxy-2-pyrimidinone 
• 259823-14-8 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-O-methyl-β-D-ribo-furanosyl]-6-(1,2-dihydroxyethyl)-4-ethoxy-2-pyrimidinone 
• 259823-12-6 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-O-methyl-β-D-ribo-furanosyl]-4-ethoxy-6-iodo-2-pyrimidinone 
• 259823-13-7 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-O-methyl-β-D-ribo-furanosyl]-4-ethoxy-6-vinyl-2-pyrimidinone 
• 259823-10-4 1-[3,5-bis-O-(tert-butyldimethylsilyl)-2-O-methyl-β-D-ribo-furanosyl]-4-ethoxy-2-pyrimidinone 
• 259823-18-2 4-ethoxy-1-(2-O-methyl-β-D-ribofuranosyl)-2-pyrimidinone 
• 3736-77-4 2,2'-Anhydrouridine 

Relevant academic research and scientific papers

Introduction of 6-formylcytidine into a MYB binding sequence

Single 6-formylcytidine was introduced into a oligonucleotide duplex (23 mers) as a substitute for thymidine in the Myb binding sequence of 3'-TTGAC- 5'. The modified duplex showed Tm of 67 °C, which was six degrees lower than the Tm of the native duplex. Binding affinity of the 23-mers to the Myb protein was estimated by electrophoretic mobility shift assays, and the binding was almost completely abolished.