259824-07-2

Upstream product

• 1226-92-2 1-phenyl-3-benzoylamino-2-buten-1-one 
• 35660-91-4 (E)-1-phenyl-2-buten-1-one 
• 55-21-0 benzamide 
• 495-41-0 1-phenylbut-2-en-1-one 
• 115245-46-0 N-(1-methoxyethyl)benzamide 
• 1575-95-7 N-acetylbenzamide 
• 13735-81-4 1-styrenyloxytrimethylsilane 

Downstream Products

• 54665-89-3 4-methyl-2,6-diphenyl-4H-1,3-thiazine 
• 259824-14-1 N-(1-methyl-3-oxo-3-phenylpropyl)benzenecarbothioamide 

Relevant academic research and scientific papers

Catalyst-free Mannich-type reaction of 1-(N-acylamino)alkyltriphenylphosphonium salts with silyl enolates

A catalyst-free reaction of 1-(N-acylamino)alkyltriphenylphosphonium tetrafluoroborates with silyl enolates was developed to prepare β-amino carbonyl compounds. The reported method is a useful approach for the preparation of N-protected β-amino esters as

Efficient Br?nsted acid-catalyzed aza-Michael reaction of amides and ureas with α,β-unsaturated enones under high-pressure conditions

A new strategy for the aza-Michael reaction of amides and ureas with α,β-unsaturated enones, which uses p-TsOH·H2O as an efficient and inexpensive catalyst under high-pressure conditions, has been developed.

Catalytic conjugate additions of nitrogen-, phosphorus-, and carbon-containing nucleophiles by amphoteric vanadyl triflate

(Chemical Equation Presented) A series of carbamates, amides, N-tosyl amides, (hetero)arenes, and hydrogen phosphines/phosphites has been examined as nucleophiles for (hetero)Michael-type additions to enones and enamides catalyzed by amphoteric vanadyl triflate under mild and neutral conditions. The newly developed C-N, C-P, and C-C bond-formation protocols were carried out smoothly in good to high yields without intervention of any 1,2-additions.

Palladium-catalyzed hydroamidation reaction of enones

A catalytic amount of Pd(PhCN)2Cl2 promotes conjugate addition reaction of amides with enones to afford β-amidoketones (aza-Michael reaction, hydroamidation reaction) under solvent-free conditions. The produced β-amidoketones could be transformed into multi-substituted piperidinones.

Sulfur-containing heterocycles: Facile synthesis of 4H-1,3-thiazines by the reaction of 3-N-acylamino ketones with Lawesson's reagent

The treatment of 3-N-acylamino ketones with Lawesson's reagent [LR: 2,4- bis(p-methoxyphenyl)-1,3,2,4-dithiaphosphetane 2,4-disulfide] afforded the sulfur-containing heterocycles, 4H-1,3-thiazines in moderate to good yields, along with the corresponding 3-N-thioacylamino ketones.