25986-11-2Relevant academic research and scientific papers
Potent and selective double-headed thiophene-2-carboximidamide inhibitors of neuronal nitric oxide synthase for the treatment of melanoma
Huang, He,Li, Huiying,Yang, Sun,Chreifi, Georges,Martásek, Pavel,Roman, Linda J.,Meyskens, Frank L.,Poulos, Thomas L.,Silverman, Richard B.
, p. 686 - 700 (2014/03/21)
Selective inhibitors of neuronal nitric oxide synthase (nNOS) are regarded as valuable and powerful agents with therapeutic potential for the treatment of chronic neurodegenerative pathologies and human melanoma. Here, we describe a novel hybrid strategy
Thiophene-2-carboximidamide Based Selective Neuronal Nitric Oxide Inhibitors
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Paragraph 0030, (2014/03/25)
Selective neuronal nitric oxide synthase (nNOS) inhibitor compounds designed with one or more thiophene-2-carboximidamide substituents for improved bioavailability.
Synthesis of a biphenyl-based cyclophane via benzidine rearrangement of a constrained m-nitrophenol derivative
Benniston, Andrew C.,Clegg, William,Harriman, Anthony,Harrington, Ross W.,Li, Peiyi,Sams, Craig
, p. 2665 - 2667 (2007/10/03)
The benzidine rearrangement of a constrained m-nitrophenol derivative results in production of a cyclophane comprising a biphenyl group and a polyether tether connected at the 4,4′ positions.
SYNTHESIS OF BAPTA-AM ANALOGUES CAPABLE OF ENHANCING THE VASCULAR PRODUCTION OF PROSTACYCLIN
Heilporn, S.,Broeders, F.,Daloze, D.,Braekman, J. C.,Boeynaems, J. M.
, p. 309 - 320 (2007/10/02)
About 30 analogues of BAPTA-AM, a potential antithrombotic agent, have been synthesized and tested for their effect on the production of prostacyclin.None of them was found to be a better enhancher of the production of prostacyclin by aortic endothelial cells than BAPTA-AM itself.The enhancing effect can be produced by compounds unable to chelate Ca2+, thus confirming that it is not related to their buffering capacity for free Ca2+.
Dipole Moments and UV Spectra of some Long-chain Molecules
Baliah, V.,Aparajithan, K.
, p. 255 - 259 (2007/10/02)
About one hundred compounds with long-chain molecular structure have been prepared (most of them are new).The dipole moments of four α,ω-bis(p-methoxyphenylthio)alkanes and five α,ω-bis(p-methoxyphenylsulphonyl)alkanes have been determined to find the effect of chain-length.In the case of sulphones, the observed values are compared with the values calculated for free rotation around all bonds intervening the end dipoles.The uv spectra of some 1,2-(distyrylsulphonyl)ethanes, and a number of α,ω-bis(arylsulphonyl)- and α,ω-bis(aryloxy)alkanes have been recorded to examine the applicability of the principle of chromophore additivity.
