259865-71-9Relevant academic research and scientific papers
Highly selective N-allylation of anilines under microwave irradiation
Liu, Meiyu,Wang, Xie,Sun, Xiaoliang,He, Wei
, p. 2711 - 2714 (2014/05/06)
An easy and rapid procedure for the preparation of a variety of mono- and bis-allylated anilines via the reaction of allyl bromide with a wide range of anilines under microwave irradiation is described. This approach allows use of mild conditions and short reaction times to give high selectivities and excellent yields.
Rhodium-catalyzed cycloisomerization: Formation of indoles, benzofurans, and enol lactones
Trost, Barry M.,McClory, Andrew
, p. 2074 - 2077 (2008/02/14)
(Chemical Equation Presented) Internal affairs: Indoles, benzofurans, and enol lactones are formed chemoselectively from the rhodium-catalyzed cyclo-isomerization reaction of easily prepared alkynyl aniline substrates (see scheme, cod = cycloocta-1,5-diene, DMF = N,N-dimethylformamide). The reaction may proceed by nucleophilic capture of a vinylidene intermediate. Indoles are formed under mild conditions using low catalyst loadings.
Palladium-catalyzed synthesis of 5- and 5,7-substituted indole derivatives
Yang, Shyh-Chyun,Chung, Wen-Hung
, p. 897 - 904 (2007/10/03)
The reaction of IPy2BF4 with anilines give the corresponding 2- iodoanilines regioselectively in high yields. N-Allyl-2-iodoanilines undergo cyclization to give 5- and 5,7-substituted indole derivatives in the presence of palladium catalysts and bases. The procedure do not require protective groups on nitrogen.
