259878-89-2Relevant academic research and scientific papers
Studies on anti-inflammatory drugs of 2-arylpropanoic acids: Part IX - A practical synthesis of ketoprofen by 1,2-aryl rearrangement
Chen, Fener,Liu, Jidong,Shao, Lanying,Yan, Qiongjiao
, p. 989 - 992 (2007/10/03)
An efficient synthesis of ketoprofen via chloration, Friedel-Crafts acylation, reduction, coupling, ketalization, rearrangement, hydrolysis and oxidation from commercially available m-bromo-benzoic acid in overall yield of about 60% has been described.
