25995-92-0

Basic information

• Product Name: 2-chloro-N-phenylbenzene-1-carbohydrazonoyl chloride
• Synonyms: 2-chloro-N-phenylbenzene-1-carbohydrazonoyl chloride
• CAS NO: 25995-92-0
• Molecular Weight: 265.142
• Mol File: 25995-92-0.mol

Chemical Properties

• CAS DataBase Reference: 2-chloro-N-phenylbenzene-1-carbohydrazonoyl chloride(CAS DataBase Reference)
• NIST Chemistry Reference: 2-chloro-N-phenylbenzene-1-carbohydrazonoyl chloride(25995-92-0)
• EPA Substance Registry System: 2-chloro-N-phenylbenzene-1-carbohydrazonoyl chloride(25995-92-0)

Safety Data

• Hazardous Substances Data: 25995-92-0(Hazardous Substances Data)

Upstream product

• 89-98-5 2-chloro-benzaldehyde 
• 609-65-4 o-chlorobenzoyl chloride 
• 100-63-0 phenylhydrazine 
• 34158-76-4 2-chlorobenzaldehyde phenylhydrazone 
• 7598-88-1 2-chlorobenzoic acid N'-phenylhydrazide 
• 204006-07-5 o-chlorobenzoic acid phenylhydrazide 

Downstream Products

• 1228272-99-8 5-(4-chloro-2-fluorophenyl)-3-(2-chlorophenyl)-1-phenyl-1a,6a-dihydropyrrolo[3,4-c]pyrazole-4,6-dione 
• 107511-22-8 3-(2-chlorophenyl)-1-phenyl-1H-1,2,4-triazol-5(4H)-one 
• 1416008-31-5 tert-butyl 4'-tert-butyl-5'-(2-chlorophenyl)-2-oxo-2'-phenyl-2',4'-dihydrospiro[indoline-3,3'-pyrazole]-1-carboxylate 
• 1321077-14-8 ethyl 3-(2-chlorophenyl)-1,4-diphenyl-1H-pyrazole-5-carboxylate 

Relevant articles and documents

Sequential [3+2] annulation reaction of prop-2-ynylsulfonium salts and hydrazonyl chlorides: Synthesis of pyrazoles containing functional motifs

A novel sequential [3+2] annulation reaction has been developed using prop-2-ynylsulfonium salts and hydrazonyl chlorides, affording a series of pyrazoles with functional motifs that can be post modified in the preparation of various drugs or drug candidates. Further transformation and gram-scale operations could also be achieved efficiently. This journal is

Synthesis of 3 H-1,2,4-Triazol-3-ones via NiCl2-Promoted Cascade Annulation of Hydrazonoyl Chlorides and Sodium Cyanate

A nickel-promoted cascade annulation reaction for the facile synthesis of 3H-1,2,4-triazol-3-ones from readily available hydrazonoyl chlorides and sodium cyanate has been developed. The transformation occurs through a cascade nickel-promoted intermolecular nucleophilic addition-elimination process, intramolecular nucleophilic addition, and a hydrogen-transfer sequence. The method has been successfully applied for the construction of the core skeleton of the angiotensin II antagonist.

Synthesis of Spirobidihydropyrazole through Double 1,3-Dipolar Cycloaddition of Nitrilimines with Allenoates

The double 1,3-dipolar cycloaddition of allenoates with nitrilimines has been achieved under mild reaction conditions, affording a variety of spirobidihydropyrazoles in moderate to excellent yields with excellent diastereoselectivities. The reaction diastereoselectively constructs double dihydropyrazole moieties and two chiral centers including a spiro carbon center.

Asymmetric catalytic 1,3-dipolar cycloaddition reaction of nitrile imines for the synthesis of chiral spiro-pyrazoline-oxindoles

A new 1,3-dipolar cycloaddition of nitrile imines with 3-alkenyl-oxindoles was catalyzed by a new chiral Mg(ClO4)2 complex of an N,N'-dioxide ligand. The reaction is so far the sole catalytic synthesis of spiro-pyrazoline-oxindole derivatives. A wide variety of substrates were explored to obtain good yields (up to 98%) and excellent enantioselectivities (up to 99%). This cycloaddition expands the scope of propargyl anion type 1,3-dipole in the construction of 2-pyrazoline subunit.

Synthesis and antifungal activities of New pyrazole derivatives via 1,3-dipolar cycloaddition reaction

A series of cycloadducts - pyrazoles via 1,3-dipolar cycloaddition reactions of generated nitrilimines with N-(4-chloro-2-fluorophenyl)maleimide were described. The novel compounds synthesized were characterized by 1H NMR, MS, and elemental analysis. The fungicidal tests showed that most of the title compounds exhibit significant fungicidal activities against Corynespora cassiicola.

Method of use, composition, and compounds

Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites. The benzoyl ring and the phenylhydrazone ring can be substituted with a halogen atom, a nitro group, or an alkyl group of from 1 to 6 carbon atoms, inclusive

Anthelmintic methods employing benzoyl chloride phenylhydrazones

Certain benzoyl chloride phenylhydrazones have been found to be active against insects and mites, and they have also been found to be effective, broad-spectrum anthelmintics for suppressing parasitic worms in animals, particularly sheep. The benzoyl ring