26000-17-9

Usage

Uses

Used in Pharmaceutical Industry:
Lycoctonine is used as an anti-inflammatory and analgesic agent for its ability to reduce inflammation and alleviate pain. Its strong anti-inflammatory properties make it a potential treatment for various inflammatory conditions, such as arthritis and rheumatism.
Used in Natural Remedies:
Lycoctonine is used as a natural remedy for treating various ailments, including arthritis, rheumatism, and other inflammatory conditions, due to its potential to alleviate pain and reduce inflammation without the side effects associated with synthetic drugs.
Research and Development:
Lycoctonine is used as a subject of research for further studies to explore its biological activity and potential medicinal uses. Scientists and researchers are interested in understanding its mechanism of action and identifying ways to harness its properties for the development of new pharmaceuticals and natural remedies for treating inflammation-related diseases and conditions.

InChI:InChI=1/C25H41NO7/c1-6-26-11-22(12-27)8-7-16(31-3)24-14-9-13-15(30-2)10-23(28,17(14)18(13)32-4)25(29,21(24)26)20(33-5)19(22)24/h13-21,27-29H,6-12H2,1-5H3/t13-,14-,15+,16+,17-,18+,19-,20+,21?,22+,23-,24+,25-/m1/s1

Upstream product

• 21019-30-7 methyllycaconitine 
• 21019-30-7 [3H]-methyllycaconitine 
• 118225-75-5 C₃₈H₅₄N₂O₁₁ 
• 143423-45-4 lycoctonine triacetate 

Downstream Products

• 129760-22-1 lycoctonine 18-O-p-phenyl-benzyl ether 
• 129760-18-5 18-(3,4,5-trimethoxybenzoyl)lycoctonine 
• 129760-16-3 18-o-anisoyllycoctonine 
• 22413-78-1 anthranoyllycoctonine 
• 1164101-67-0 anthranoyllycoctonine 
• 25488-62-4 delphatine 
• 129760-15-2 18-p-anisoyllycoctonine 

Relevant academic research and scientific papers

REACTIONS OF LYCOCTONINE ALKALOIDS WITH ACETIC ANHYDRIDE AND p-TOLUENESULFONIC ACID

The reactions of alkaloids having a 7,8-diol system - lycoctonine, browniine, and dihydromonticoline - with acetic anhydride and p-toluenesulfonic acid have been studied.The optimum conditions for this reaction, leading to anhydro compounds, have been found.

N-ACETYLSEPACONITINE - A NEW ALKALOID FROM Aconitum leucostomum

The structure of the new alkaloid N-acetylsepaconitine, and also of a base (IV) formed from lycaconitine in the process of ethanolic extraction in an alkaline medium have been determined on the basis of spectral characteristics.Both bases were isolated from the epigeal part of Aconitum leucostomum.

Covalent attachment of antagonists to the α7 nicotinic acetylcholine receptor: Synthesis and reactivity of substituted maleimides

The 3-methylmaleimide congeners of the natural product methyllycaconitine (MLA) and an analogue covalently attach to functional cysteine mutants of the α7 nicotinic acetylcholine receptor (nAChR).

Nudicauline and elatine as potent norditerpenoid ligands at rat neuronal α-bungarotoxin binding sites: Importance of the 2-(methylsuccinimido)benzoyl moiety for neuronal nicotinic acetylcholine receptor binding

Methyllycaconitine (MLA, 1) is a novel, potent probe for mammalian and insect nicotinic acetylcholine receptors (nAChR) and displays remarkable selectivity toward neuronal [125I]-α-bungarotoxin (αBgTX) binding sites that correspond to α7-type n

Rapid and Efficient Isolation of the Nicotinic Receptor Antagonist Methyllycaconitine from Delphinium: Assignment of the Methylsuccinimide Absolute Stereochemistry as S

Methyllycaconitine (MLA) has been isolated from Garden Hybrid Delphinium and purified by vacuum liquid chromatography. 13C NMR and optical rotation has been used to characterize the absolute configuration of the methylsuccinimide moiety as S.Ligand binding assays confirmed the potency of MLA and its selectivity for α-bungarotoxin-sensitive neuronal nicotinic acetylcholine receptors.

THE DITERPENOID ALKALOIDS OF DELPHINIUM DELAVAYI FRANCH VAR. POGONANTHUM (H.-M.) WANG

Investigation of the alkaloids of Delphinium delavayi Franch var. pogonanthum (H-M) Wang has led to the isolation of nine known alkaloids and a new pair of regioisomeric alkaloids delavaine A (10A) and delavaine B (10B) whose structures have been determined based on spectroscopic evidence and two syntheses from methyllycaconitine (3).The known alkaloids that were isolated are the C19-diterpenoid alkaloids: deltaline (1), deltamine (2), methyllycaconitine (3), anthranoyllycaconitine (4), lycoctonine (5), delsemine (6), and the C20-diterpenoid alkaloids: hetisinone (7), hetisine (8), and ajaconine (9).Delsemine (6) has been synthesized from methyllycaconitine and chromatographically separated into its component regioisomers 6A and 6B.