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260046-09-1

(2S)-2-[[4-[(2-amino-6-ethyl-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid, commonly known as Sitagliptin, is a pharmaceutical compound that serves as a medication for the treatment of type 2 diabetes. It functions as a dipeptidyl peptidase-4 (DPP-4) inhibitor, which increases the levels of incretin hormones in the body, thereby aiding in the regulation of blood sugar levels. Sitagliptin is administered orally and is often used in conjunction with other diabetes medications such as metformin. It is crucial to adhere to the dosage and usage guidelines provided by healthcare professionals to effectively manage diabetes and mitigate the risk of associated complications.

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  • 260046-09-1 Structure

  • Basic information

    1. Product Name: (2S)-2-[[4-[(2-amino-6-ethyl-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid
    2. Synonyms: (2S)-2-[[4-[(2-amino-6-ethyl-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid
    3. CAS NO:260046-09-1
    4. Molecular Formula:
    5. Molecular Weight: 284.543
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 260046-09-1.mol

  • Chemical Properties

    1. Melting Point: N/A
    2. Boiling Point: N/A
    3. Flash Point: N/A
    4. Appearance: N/A
    5. Density: N/A
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. CAS DataBase Reference: (2S)-2-[[4-[(2-amino-6-ethyl-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid(CAS DataBase Reference)
    10. NIST Chemistry Reference: (2S)-2-[[4-[(2-amino-6-ethyl-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid(260046-09-1)
    11. EPA Substance Registry System: (2S)-2-[[4-[(2-amino-6-ethyl-4-oxo-1,7-dihydropyrrolo[2,3-d]pyrimidin-5-yl)sulfanyl]benzoyl]amino]pentanedioic acid(260046-09-1)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 260046-09-1(Hazardous Substances Data)

260046-09-1 Usage

Uses

Used in Pharmaceutical Industry:
Sitagliptin is utilized as an antidiabetic medication for the management of type 2 diabetes. It operates by inhibiting the DPP-4 enzyme, which in turn increases the levels of incretin hormones, helping to control blood sugar levels. This medication is often prescribed alongside other diabetes drugs, such as metformin, to enhance the overall effectiveness of diabetes management.

Check Digit Verification of cas no

The CAS Registry Mumber 260046-09-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,0,0,4 and 6 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 260046-09:
(8*2)+(7*6)+(6*0)+(5*0)+(4*4)+(3*6)+(2*0)+(1*9)=101
101 % 10 = 1
So 260046-09-1 is a valid CAS Registry Number.

260046-09-1Relevant articles and documents

4-Aminoquinoline-Pyrimidine hybrids: Synthesis, antimalarial activity, heme binding and docking studies

Kumar, Deepak,Khan, Shabana I.,Tekwani, Babu L.,Ponnan, Prija,Rawat, Diwan S.

, p. 490 - 502 (2014/12/11)

A series of novel 4-aminoquinoline-pyrimidine hybrids has been synthesized and evaluated for their antimalarial activity. Several compounds showed promising in vitro antimalarial activity against both CQ-sensitive and CQ-resistant strains with high select

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