26020-48-4

Usage

Uses

Used in Pharmaceutical Industry:
3,4,5-Trichlorothiophene-2-carboxylic acid is used as a building block in the synthesis of various pharmaceuticals for its potential to contribute to the development of new drugs with diverse therapeutic applications. Its unique structure allows for the creation of a wide range of chemical compounds with different biological activities.
Used in Agrochemical Industry:
In the agrochemical industry, 3,4,5-Trichlorothiophene-2-carboxylic acid is utilized as a key intermediate in the production of various agrochemicals, such as pesticides and herbicides. Its reactivity and structural features enable the synthesis of compounds with effective pesticidal properties, contributing to crop protection and yield enhancement.
Used in Medicinal Chemistry Research:
3,4,5-Trichlorothiophene-2-carboxylic acid is also used as a subject of interest in medicinal chemistry research. Its potential biological activities and unique structural features make it a promising candidate for the development of new therapeutic agents and the exploration of novel chemical spaces in drug discovery.

InChI:InChI=1/C5HCl3O2S/c6-1-2(7)4(8)11-3(1)5(9)10/h(H,9,10)

Upstream product

• 6012-97-1 2,3,4,5-tetrachlorothiophene 
• 71105-25-4 3,4,5-trichloro-2-thiophenecarbonitrile 
• 124-38-9 carbon dioxide 
• 78665-33-5 C₄BrCl₃MgS 
• 17249-78-4 2,3,4-trichlorothiophene 

Downstream Products

• 24422-15-9 3,4,5-Trichlorothien-2-carboxylic acid chloride 
• 17249-78-4 2,3,4-trichlorothiophene 
• 34721-65-8 perchloro-2,2'-bithiophene 
• 1393456-36-4 C₁₅H₆Cl₃F₃OS 
• 109-52-4 valeric acid 
• 81730-28-1 3,4,5-Trichloro-thiophene-2-carboxylic acid benzyl ester 
• 81730-19-0 3,4,5-trichlorothiophen-2-carboxylic acid ethyl ester 
• 81730-20-3 3,4,5-Trichloro-thiophene-2-carboxylic acid propyl ester 
• 81730-18-9 methyl 3,4,5-trichloro-2-thiophenecarboxylate 

Relevant academic research and scientific papers

The Reaction of 2,3,4-Trichlorothiophene with Alkyllithium Reagents

2,3,4-Trichlorothiophene undergoes metal-hydrogen exchange with one equivalent of butyllithium in THF at -78 deg C to give trichloro-2-thienyllithium in 91percent yield.No metal-halogen exchange is observed to have taken place.With t-butyllithium under similar conditions, however, the metal-halogen exchange reaction occurs but only to the extent of 8percent; the main reaction remains to be the metal-hydrogen exchange. 2,3,4-Trichlorothiophene reacts with two equivalents of butyllithium in ether at -5 deg C to give 3,4-dichloro-2,5-dilithiothiophene in 96percent yield. - Keywords: 3,4-Dichloro-2,5-dilithiothiophene; Lithium-chlorine exchange; Trichloro-2-thienyllithium; 2,3,4-Trichlorothiophene

INVESTIGATIONS IN THE FIELD OF THE CHLORINATION OF ORGANIC COMPOUNDS AND THE TRANSFORMATIONS OF THE CHLORINE DERIVATIVES. XVII. SYNTHESIS OF NEW DERIVATIVES OF TRICHLOROTHIOPHENE FROM 3,4,5-TRICHLORO-2-THIOPHENECARBOXYLIC ACID

The amide, anhydride, peroxide, and a series of esters and other derivatives were synthesized from 3,4,5-trichloro-2-thiophenecarboxylic acid.

Reaction of 2,3,4-Trichlorothiopene and Tetrachlorothiophene with Ethylmagnesium Bromide. Preparation of Trichloro-2-thienylmagnesium Bromide and 2,5-Bis(Bromomagnesium)-3,4-Dichlorothiophene

Metal-hydrogen exchange between ethylmagnesium bromide and 2,3,4-trichlorothiophene in THF gives trichloro-2-thienylmagnesium bromide in at least 86percent yield.Similarly, metal-halogen exchange between tetrachlorothiophene and ethylmagnesium bromide produces trichloro-2-thienylmagnesium bromide in 84percent yield.The reaction of two and a half equivalents of ethylmagnesium bromide with 2,3,4-trichlorothiophene yields a mixture of trichloro-2-thienylmagnesium bromide (40percent) and 2,5-bis(Bromomagnesium)-3,4-dichlorothiophene (41percent).The Grignard reagents were characterised by converting them into the corresponding known trimethylsilylderivatives and carboxylic acids.