260252-87-7

Usage

Usage

Mainly in research and pharmaceutical applications

Composition

Piperazine molecule with a hydrochloride salt and a nitrophenyl group attached

Potential Applications

Antidepressant, antipsychotic, and anxiolytic agent

Role

Treatment of central nervous system disorders

Mechanism

Modulates dopamine and serotonin levels in the brain

Function

Potential ligand for various neurotransmitter receptors

Research Use

Studying mechanisms of action of psychiatric drugs and developing new therapeutic agents for mental health disorders

Upstream product

• 182618-86-6 tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate 
• 350-46-9 4-Fluoronitrobenzene 

Downstream Products

• 1215504-60-1 4-(piperazin-1-yl)aniline hydrochloride 
• 182618-86-6 tert-butyl 4-(4-nitrophenyl)piperazine-1-carboxylate 
• 947673-13-4 benzyl 4-(4-nitrophenyl)piperazine-1-carboxylate 
• 1616295-76-1 C₂₃H₂₅N₅O₄ 
• 1393900-82-7 lithium 2-(2-(2-(2-((4-(4-(tert-butoxycarbonyl)piperazin-1-yl)phenyl)amino)-5-(trifluoromethyl)pyrimidin-4-yl)ethyl)phenyl)acetate 
• 886968-54-3 2-{4-amino-6-[4-(4-nitrophenyl)piperazin-1-yl]-1,3,5-triazin-2-yl}acetonitrile 

Relevant academic research and scientific papers

Pyrrolopyrimidine compound, pharmaceutical composition containing thereof, and preparation method and applications

The invention relates to a pyrrolopyrimidine compound represented by formula I, a pharmaceutical composition containing thereof, and a preparation method and applications in preventing or treating Weel protein kinase related diseases.

PYRIDONE-SUBSTITUTED-DIHYDROPYRAZOLOPYRIMIDINONE DERIVATIVE

The invention relates to a compound of general formula (I-0): wherein R1 means a C1-C6 alkyl group, a C2-C6 alkenyl group, a C2-C6 alkynyl group, or a C3-C6 cycloalkyl group; R2, R3, R4 and R5 mean a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, or a halo-C1-C6 alkoxy group; R6 means a hydrogen atom, or a C1-C6 alkyl group; R7a means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group, a hydroxy-C1-C6 alkyl group, -Q2-N(R1c)R1d or a nitrogen-containing heterocyclic group; R8a means a hydrogen atom, a halogen atom, a C1-C6 alkyl group, a halo-C1-C6 alkyl group, a C1-C6 alkoxy group or a hydroxy-C1-C6 alkyl group; or R7a and R8a form, as taken together, a C2-C6 alkylene group, or R7a and R8a and the ring atoms to which they bond may form a spiro ring or a bicyclo ring; and X and Y mean a methine group or a nitrogen atom. The compound of the invention has, based on its excellent Wee1 kinase-inhibitory effect, a cell growth-inhibitory effect and an additive/synergistic effect with any other anticancer agent, and is therefore useful in the field of medicine.