260252-90-2Relevant academic research and scientific papers
Thiazole analogues of the NSAID indomethacin as selective COX-2 inhibitors
Woods, Keith W.,McCroskey, Richard W.,Michaelides, Michael R.,Wada, Carol K.,Hulkower, Keren I.,Bell, Randy L.
, p. 1325 - 1328 (2007/10/03)
The carboxyl group of the NSAID indomethacin was replaced with a variety of substituted thiazoles to obtain a series of potent, selective inhibitors of COX-2. Additional substitutions were made at the 1-position and 5-position of the indole of indomethacin.
