26028-63-7

Basic information

• Product Name: 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL
• Synonyms: SALOR-INT L321443-1EA;5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL;AKOS BBS-00003367;CHEMBRDG-BB 3017967;ART-CHEM-BB B017967;Albb-003245;5-(3-chlorophenyl)-4-ethyl-4H-1,2,4-triazole-3-thiol(SALTDATA: FREE);5-(3-chlorophenyl)-4-ethyl-2H-1,2,4-triazole-3-thione
• CAS NO: 26028-63-7
• Molecular Formula: C₁₀H₁₀ClN₃S
• Molecular Weight: 239.72
• Mol File: 26028-63-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 324.2°Cat760mmHg
• Flash Point: 149.9°C
• Appearance: /
• Density: 1.37g/cm³
• Vapor Pressure: 0.000249mmHg at 25°C
• Refractive Index: 1.674
• CAS DataBase Reference: 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL(26028-63-7)
• EPA Substance Registry System: 5-(3-CHLOROPHENYL)-4-ETHYL-4H-1,2,4-TRIAZOLE-3-THIOL(26028-63-7)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 26028-63-7(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H10ClN3S/c1-2-14-9(12-13-10(14)15)7-4-3-5-8(11)6-7/h3-6H,2H2,1H3,(H,13,15)

Upstream product

• 26036-05-5 1-(3-chlorobenzoyl)-4-ethylthiosemicarbazide 
• 1673-47-8 3-chlorobenzhydrazide 

Downstream Products

• 1426945-74-5 7-[4-{[3-(3-Chlorophenyl)-4-ethyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-1-yl]methyl}piperazin-1-yl]-1-cyclopropyl-6-fluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid 

Relevant articles and documents

Synthesis, characterization and preliminary anticonvulsant evaluation of some 4-alkyl-1,2,4-triazoles

Designed and synthesized 4-alkyl-1,2,4-triazole-3-thione derivatives showed significant anticonvulsant activity, determined in the maximal electroshock-induced seizure (MES) test. The chemical structure of all new compounds was confirmed by spectral methods (1H NMR, 13C NMR, IR, MS). A sensitive and selective method was elaborated for the determination of the anticonvulsant compounds levels in mice brain tissue, based on HPLC with diode array detector (DAD). Chromatographic tests showed that lack of anticonvulsant effect of two derivatives (15, 16) with long alkyl chains at N-4 position of the 1,2,4-triazole ring was due to the inability to cross the blood-brain barrier (BBB).

NEW COMPOUNDS

The present invention relates to new compounds of formula I, (I) a process for their preparation and new intermediates prepared therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.