26029-01-6

Basic information

• Product Name: 4-ETHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL
• Synonyms: 3H-1,2,4-Triazole-3-thione,4-ethyl-2,4-dihydro-5-(4-pyridinyl)-;4-ethyl-5-(4-pyridinyl)-4H-1,2,4-triazole-3-thiol;4-ethyl-5-(4-pyridyl)-2H-1,2,4-triazole-3-thione;4-ethyl-5-pyridin-4-yl-2H-1,2,4-triazole-3-thione;4H-[1,2,4]Triazole-3-thiol, 4-ethyl-5-pyridin-4-yl-
• CAS NO: 26029-01-6
• Molecular Formula: C₉H₁₀N₄S
• Molecular Weight: 206.27
• Mol File: 26029-01-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 309°C at 760 mmHg
• Flash Point: 140.7°C
• Appearance: /
• Density: 1.34g/cm³
• Vapor Pressure: 0.000656mmHg at 25°C
• Refractive Index: 1.699
• CAS DataBase Reference: 4-ETHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-ETHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL(26029-01-6)
• EPA Substance Registry System: 4-ETHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL(26029-01-6)

Safety Data

• Hazardous Substances Data: 26029-01-6(Hazardous Substances Data)

Usage

General Description

4-ETHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL is a chemical compound that belongs to the family of triazoles. It features a 4-ethyl and 5-pyridin-4-yl substitution on the triazole ring, with a thiol group attached to the 3-position. 4-ETHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL has potential applications in the field of medicinal chemistry, particularly in the development of new drugs and pharmaceuticals. It may also have uses in agricultural and industrial processes as a functional group in the synthesis of various organic compounds. The specific properties and potential uses of 4-ETHYL-5-PYRIDIN-4-YL-4H-[1,2,4]TRIAZOLE-3-THIOL would need to be further studied and evaluated for its practical applications.

InChI:InChI=1/C9H10N4S/c1-2-13-8(11-12-9(13)14)7-3-5-10-6-4-7/h3-6H,2H2,1H3,(H,12,14)

Upstream product

• 54-85-3 isoniazid 
• 26036-34-0 4-ethyl-1-(4-pyridylcarbonyl)thiosemicarbazide 
• 542-85-8 Ethyl isothiocyanate 
• 2459-09-8 4-pyridinecarboxylic acid, methyl ester 
• 24066-82-8 ethyl 2-isothiocyanatoacetate 

Downstream Products

• 585550-72-7 C₂₀H₂₃N₅OS 
• 150536-05-3 2-(4-Ethyl-5-pyridin-4-yl-4H-[1,2,4]triazol-3-ylsulfanyl)-propionic acid 

Relevant articles and documents

A first-in-class anticancer dual HDAC2/FAK inhibitors bearing hydroxamates/benzamides capped by pyridinyl-1,2,4-triazoles

Novel 5-pyridinyl-1,2,4-triazoles were designed as dual inhibitors of histone deacetylase 2 (HDAC2) and focal adhesion kinase (FAK). Compounds 5d, 6a, 7c, and 11c were determined as potential inhibitors of both HDAC2 (IC50 = 0.09–1.40 μM) and F

Synthesis and Intramolecular Heterocyclization of Selected Isonicotinic Acid Thiocarbazides

The reaction of isonicotinic acid hydrazide with ethyl-, allyl-, and cinnamoyl isothiocyanates has afforded the corresponding alkylthiosemicarbazides and the products of their intramolecular heterocyclization, 1,2,4-triazoles.

Narrow SAR in odorant sensing Orco receptor agonists

The systematic exploration of a series of triazole-based agonists of the cation channel insect odorant receptor is reported. The structure-activity relationships of independent sections of the molecules are examined. Very small changes to the compound structure were found to exert a large impact on compound activity. Optimal substitutions were combined using a 'mix-and-match' strategy to produce best-in-class compounds that are capable of potently agonizing odorant receptor activity and may form the basis for the identification of a new mode of insect behavior modification.