26031-63-0

Usage

Uses

Used in Pharmaceutical Synthesis:
1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide is used as an intermediate in the pharmaceutical industry for the synthesis of various drugs. Its unique structure allows it to participate in a range of chemical reactions, facilitating the creation of diverse medicinal compounds.
Used in Organic Synthesis:
In the field of organic chemistry, 1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide is used as a reactant in multiple chemical reactions. Its presence can lead to the formation of new organic compounds with potential applications in various industries.
Used in Drug Development:
Due to its distinctive chemical structure, 1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide may have potential applications in the development of new drugs. Researchers can explore its properties to create novel pharmaceuticals with improved efficacy and fewer side effects.
Used in Material Science:
The unique properties of 1-(2-(4-fluorophenyl)-2-oxoethyl)pyridine-1-ium bromide may also find applications in the development of new materials. Its chemical structure could be harnessed to create materials with specific characteristics, such as improved stability or reactivity, for use in various industrial applications.

Upstream product

• 110-86-1 pyridine 
• 403-29-2 2-bromo-4'-fluoroacetophenone 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 78938-17-7 [6-(4-Fluoro-benzoyl)-1,4-di-pyridin-3-yl-1,4-dihydro-[1,2,4,5]tetrazin-3-yl]-(4-fluoro-phenyl)-methanone 
• 129155-23-3 2-ethylthio-3-(4'-fluorophenacyl)-1,4-naphthoquinone 
• 76609-29-5 2-(4-fluorophenyl)-1H-benzo[g]indole 
• 76609-18-2 5-methyl-2-(4'-fluoro)phenyl-1H-indole 
• 76609-16-0 5-chloro-2-(4-fluorophenyl)-1H-indole 
• 76609-19-3 2-(4-fluorophenyl)-5-methoxy-1H-indole 
• 76609-17-1 5-bromo-2-(4-fluorophenyl)-1H-indole 
• 1233194-42-7 C₂₄H₁₅FN₂OS 
• 1233194-43-8 C₂₅H₁₇FN₂OS 
• 1233194-44-9 C₂₅H₁₇FN₂O₂S 
• 1437790-38-9 (1,2-dihydronaphtho[2,1-b]furan-2-yl)(4-fluorophenyl)methanone 

Relevant academic research and scientific papers

Anti-tubercular activity and molecular docking studies of indolizine derivatives targeting mycobacterial InhA enzyme

A series of 1,2,3-trisubstituted indolizines (2a–2f, 3a–3d, and 4a–4c) were screened for in?vitro whole-cell anti-tubercular activity against the susceptible H37Rv and multidrug-resistant (MDR) Mycobacterium tuberculosis (MTB) strains. Compounds 2b–2d, 3a

Silver-Promoted (4 + 1) Annulation of Isocyanoacetates with Alkylpyridinium Salts: Divergent Regioselective Synthesis of 1,2-Disubstituted Indolizines

An unprecedented silver-promoted regioselective (4 + 1) annulation of isocyanoacetates with pyridinium salts is reported. The established protocol provides controlled, facile, and modular access to a range of synthetically useful N-fused heterocyclic scaffolds containing indolizines, pyrrolo[1,2-a]quinolines, pyrrolo[2,1-a]isoquinolines, and 1H-imidazo[4,5-a]indolizin-2(3H)-ones. A mechanistic pathway involving nucleophilic addition/protonation/elimination/cycloisomerization is proposed.

Base-mediated 1,3-dipolar cycloaddition of pyridinium bromides with bromoallyl sulfones: a facile access to indolizine scaffolds

An expedient and transition-metal-free synthetic strategy has been developed for the construction of substituted indolizines from a unique combination of pyridinium salts and 2-bromoallyl sulfones. This approach does not compromise with the diverse substitutions on both the pyridinium salts and 2-bromoallyl sulfones. Wide substrate scope, operational simplicity, milder reaction conditions and good to moderate yields are the merits associated with the current approach. Moreover, this method provides two products which are amenable for the generation of a library of key indolizine building blocks. This journal is

Highly Fluorinated Ir(III)-2,2′:6′,2″-Terpyridine-Phenylpyridine-X Complexes via Selective C-F Activation: Robust Photocatalysts for Solar Fuel Generation and Photoredox Catalysis

A series of fluorinated Ir(III)-terpyridine-phenylpyridine-X (X = anionic monodentate ligand) complexes were synthesized by selective C-F activation, whereby perfluorinated phenylpyridines were readily complexed. The combination of fluorinated phenylpyridine ligands with an electron-rich tri-tert-butyl terpyridine ligand generates a "push-pull" force on the electrons upon excitation, imparting significant enhancements to the stability, electrochemical, and photophysical properties of the complexes. Application of the complexes as photosensitizers for photocatalytic generation of hydrogen from water and as redox photocatalysts for decarboxylative fluorination of several carboxylic acids showcases the performance of the complexes in highly coordinating solvents, in some cases exceeding that of the leading photosensitizers. Changes in the photophysical properties and the nature of the excited states are observed as the compounds increase in fluorination as well as upon exchange of the ancillary chloride ligand to a cyanide. These changes in the excited states have been corroborated using density functional theory modeling.

Synthesis of novel 2-aryl-3-benzoyl-1H-benzo[f]indole-4,9-diones using a domino reaction

A convenient one-pot multicomponent synthetic approach was developed for the synthesis of novel 2-aryl-3-benzoyl-1H-benzo[f]indole-4,9-diones using 2-amino-1,4-naphthoquinone, N-acylmethylpyridinium bromides, and a variety of aromatic aldehydes.

Greener synthesis of indolizine analogues using water as a base and solvent: study for larvicidal activity against Anopheles arabiensis

Greener synthesis of a series of novel indolizine analogues have been achieved by the cyclization of aromatic cycloimmonium ylides with electron-deficient alkynes in the presence of water as the base and solvent at 80?°C. Yield of the title compounds was

SMALL MOLECULE C-MYC INHIBITORS

This invention provides small molecule Myc-inhibitors. Also provided in the invention are therapeutic applications of these compounds for treating Myc-driven cancer and other related methods.

Discovery of indolizines containing triazine moiety as new leads for the development of antitumoral agents targeting mitotic events

Abstract A new family of 3-aroylindolizines bearing a dimethoxytriazine unit in their position 1 was designed, synthesized and evaluated for their ability to inhibit tubulin polymerization and cellular growth in vitro. Compound 39 was the best candidate i

Microwave-assisted, one-pot three component synthesis of 2-phenyl H-imidazo[1, 2-α]pyridine

A novel synthesis of 2-phenylH-imidazio[1, 2-α] pyridines is described from a one-pot, three-component reaction between pyridine, guanidine (urea or thiourea) and α-bromoketones under microwave irradiation and solvent-free conditions in excellent yields.

Cascade reactions of diazocarbonyl compounds with pyridinium aroylmethylides accompanied by water or benzoic acid elimination in the cyclocondensation step

The reaction of pyridinium aroylmethylides with diazocarbonyl compounds proceeds as a multistep process involving three ylide molecules and one diazo compound molecule. As a result, intermediate functionally substituted azines, if they contain carbonyl gr