26036-25-9

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 5351-23-5 4-hydroxybenzoic acid hydrazide 
• 99-76-3 methyl 4-hydroxylbenzoate 
• 120-47-8 Ethyl 4-hydroxybenzoate 

Downstream Products

• 26028-88-6 2,4-dihydro-5-(4-hydroxyphenyl)-4-phenyl-3H-1,2,4-triazole-3-thione 
• 135848-72-5 Pd(C₆H₅NHCSNHNHCOC₆H₄-p-OH)Cl₂ 
• 1207372-09-5 C₂₂H₁₇N₃O₃S 
• 1207371-64-9 C₁₆H₁₃N₃O₃S 
• 1207371-73-0 C₂₂H₁₇N₃O₂S 
• 1207372-00-6 C₂₃H₁₉N₃O₂S 
• 1207371-82-1 C₂₂H₁₆ClN₃O₂S 
• 1207371-91-2 C₂₂H₁₆BrN₃O₂S 
• 1207372-18-6 C₂₃H₁₉N₃O₃S 
• 1355947-38-4 1,2,4,5-tetrakis[5-(4-hydroxyphenyl)-4-phenyl-1,2,4-triazol-3-ylthiomethyl]benzene 
• 78874-81-4 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole 

Relevant academic research and scientific papers

Design and synthesis of some new 1,3,4-thiadiazines with coumarin moieties and their antioxidative and antifungal activity

A series of newly disubstituted (compounds 4a,b) and trisubstituted 1,3,4-thiadiazines 5a-l with various substituents was prepared utilizing different thiosemicarbazides and 3-A-bromoacetylcoumarins as starting compounds. The structures of the synthesized

Mn(II) catalyzed synthesis of 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole: Crystal structure, DFT, molecular docking, Hirshfeld surface analysis, and in vitro anticancer activity on DL cells

The syntheses and screening of novel synthetic molecules have gained attention as a potential therapeutic agent in the treatment of cancer. In the present study, a new compound 5(4-hydroxyphenyl)-2-(N-phenylamino)-1,3,4-oxadiazole (Hppo) has been synthesized and its anticancer activity is investigated against Dalton's lymphoma (DL) tumor cells derived from murine T-cell lymphoma. The Hppo has been characterized through IR, NMR, and single-crystal X-ray data. The structure of Hppo is stabilized via hydrogen bonding interactions and crystallizes in an orthorhombic system with space group P b c n. The fingerprint plots associated with Hirshfeld surface analysis indicate that there are different types of weak interactions viz. C-H···N, O-H···N and C-H···O. The DFT calculations are also performed to verify physiochemical properties of Hppo and the results obtained are in good agreement with the experimental results. The HOMO and LUMO energy gap of 7.344 eV for Hppo indicates good NLO properties. The cytotoxicity activity of Hppo is tested against Dalton's lymphoma cells using MTT assay which reveals that the compound showed admirable anticancer activity (IC50= 50 μg/mL), which is better than many previously reported compounds. The mechanism of action of Hppo is investigated by performing different biological studies and the results obtained reveal that Hppo acts through down-regulating mitochondrial membrane potential and up-regulating reactive oxygen species production. Molecular docking studies are also performed to obtain more insights on biological activities of Hppo and its mode of action against CYP-19 (PDB: 3EQM), JAK2 (PDB: 5AEP), BCL-2 (PDB: 2O2F), and caspase3 (PDB: 1RE1), and result displayed favorable binding interactions with binding energy -7.43, -7.96, -6.61, and -6.88 Kcal/mol.

A KHSO4 mediated facile synthesis of 2-amino-1,3,4-oxadiazole derivatives

A novel, efficient and mild KHSO4 mediated synthesis for 2-amino-1,3,4-oxadiazoles has been established via the cyclodesulfurization of benzoylhydrazine and isothiocyanate derivatives in one pot. The reactions proceeded smoothly at room tempera

Compound as well as preparation method and application thereof as c-Met inhibitor

The invention provides a compound as well as a preparation method and application thereof as a c-Met inhibitor. The compound has a structure as shown in a formula (X) or an isomer of the compound in the formula (X) or a pharmaceutically acceptable slat of the compound, wherein A is hydrogen or B is shown as the specification or C does not exist or is a benzene ring, and C forms a quinazoline grouptogether with a parent nucleus structure when being the benzene ring; L1 is -NH-CH2- or -O-; L2 does not exist or is -NH-; X is C or N; Y is O or S; R1 is halogen or -NO2; R2 is shown as the specification or is -COR5; R3 is selected from halogen, alkyl and alkoxy; each of R4 and R5 is an independent C3-C6 saturated or unsaturated cycloalkyl, aryl or heteroaryl; and the cycloalkyl, aryl or heteroaryl is substituted or unsubstituted, the substituent group is selected from halogen, nitryl, alkyl and substituent alkyl.

Synthesis of a series of novel tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole and 1,3,4-oxadiazole derivatives

A series of tetra-tert-butylcalix[4]arene linked to 1,2,4-triazole-5-thiones and 1,3,4-oxadiazole-5-thiones derivatives at lower rim were synthesized by the reaction of 1,2,4-triazole-5-thione and 1,3,4-oxadiazole-5-thione with 5,11,17,23-tetra-tert-butyl-25,27-bis(3-bromopropoxy)-26,28-dihydroxycalix[4]arene (2). The synthesized compounds were characterized by FT-IR, 1H NMR, 13C NMR spectral data, elemental analysis and ESI-MS.

Structure-activity relationship studies of microbiologically active thiosemicarbazides derived from hydroxybenzoic acid hydrazides

Forty-five derivatives of thiosemicarbazide were synthesized, and their antibacterial activity against Gram-positive and Gram-negative bacteria was evaluated. Some of the described compounds exhibited interesting activity against reference strains of Gram

Synthesis and structure of new 1,2,4-triazoles derived from p-hydroxybenzoic acid hydrazide

Hydrolysis of thiosemicarbazides obtained by reacting p-hydroxybenzoic acid hydrazide with alkyl isocyanates occurs via intramolecular heterocyclization affording substituted 4-3-(4-hydroxyphenyl)-1H-1,2,4-triazole-5(4H)-thiones in a high yield.

Synthesis of 1,2,4,5-tetrakis(1,2,4-triazolyl) benzene and 1,2,4,5-tetrakis(1,3,4-oxadiazolyl) benzene derivatives

A series of 1,2,4,5-tetrakis(1,2,4-triazolyl)benzenes and 1,2,4,5-tetrakis(1,3,4-oxadiazolyl)benzenes was synthesized by nucleophilic addition of sodium salts of 4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thiones and 1,3,4-oxadiazole-2(3H)-thiones to 1,2,4,5-tetrakis(bromomethyl)benzene. The structure of the newly synthesized compounds was confirmed by elemental analysis, IR and 1H and 13C NMR spectra. Supplemental materials are available for this article. Go to the publisher's online edition of Phosphorus, Sulfur, and Silicon and the Related Elements for the following free supplemental resource: 1H and 13C NMR spectra of products (Figures S1-S24).

Synthesis, antihypertensive activity, and 3D-QSAR studies of some new p-hydroxybenzohydrazide derivatives

p-Hydroxybenzohydrazide 2 on treatment with aromatic/aliphatic aldehyde followed by cyclization with carbon disulphide afforded compounds 4a-4n. Also, compound 2 by treatment of substituted isothiocyanate followed by the treatment of chloroacetic acid yields the corresponding compounds 6a-6i. All the test compounds were assayed for antihypertensive activity by non-invasive blood pressure measurement and invasive blood pressure measurement methods. The test compounds showed significant antihypertensive activity. The intact compounds were subjected to 3D-QSAR studies. The 3D-QSAR analysis was carried out by PHASE program and a statistically reliable model with good predictive power (r 2a=a0.98, q2a=a0.74) was achieved. The 3D-QSAR plots illustrated insights into the structure-activity relationship of these compounds which may aid in the design of potent p- hydroxybenzohydrazide derivatives as antihypertensive agents. One third of the world population is affected with cardiovascular diseases and the major part of it means hypertension. With the aim of obtaining new agents which might have a better or similar antihypertensive activity as the known standards, some novel p-hydroxybenzohydrazide derivatives were synthesized and tested. Copyright

Synthesis and 3D-QSAR of p-hydroxybenzohydrazide derivatives with antimicrobial activity against multidrug-resistant Staphylococcus aureus

Hospital-acquired methicillin-resistant Staphylococcus aureus (MRSA) has been an increasing problem worldwide since the initial reports over 40 years ago. To examine new drug leads with potential antibacterial activities, Various N'-[(-3-substituted-4- oxo-1,3-thiazolidin-2-ylidene]-4-hydroxy benzohydrazide (4a-4.i) and N'-[-(3,4-disubstituted)-1,3-thiazolidin-2ylidene)]-4- hydroxybenzohydrazide from (5.a-5.i) to (10.a-10.i) were synthesized using appropriate synthetic route. The entire test compounds (4.a-4.i) and from (5.a-5.i) to (10.a-10.i) were assayed in vitro against s. aureus strain. The minimum inhibitory concentration (MIC) was determined for test compounds and for reference standards. The test compounds showed significant antibacterial activity against the strains used, when tested in vitro. In general, p-hydroxybenzohydrazide ring and substituted thiazoline ring are essential for antimicrobial activity. Among the compounds tested, compounds 6.f, 7.g, 9.f and 10.f, 10 i were found to be most potent. The test compounds were found nontoxic upto the dose level of 2000 μg/mL. The intact compounds were then subjected for 3D-QSAR studies. 3D-QSAR study based on the principal of alignment of pharmacophoric features by Schroedinger PHASE module. The 3D-QSAR study allowed us to confirm the preferential binding mode of p-hydroxybenzohydrazide inside the active site.