26038-62-0

Usage

Type of chemical compound

Selective dopamine transporter ligand

Potential use

Treatment of drug addiction and neurological disorders (e.g. Parkinson's disease)

Mechanism of action

High affinity for the dopamine transporter, which regulates dopamine levels in the brain

Additional potential use

Radiotracer for imaging dopamine transporters in the brain, valuable for neuroscience research and drug development.

Upstream product

• 107-15-3 ethylenediamine 
• 645-59-0 dihydrocinnamonitrile 
• 104-53-0 3-phenyl-propionaldehyde 
• 272110-20-0 1-tert-butyloxycarbonyl-2-(2-phenylethyl)-2-imidazoline 
• 68175-79-1 3-phenyl-propionimidic acid methyl ester 

Relevant academic research and scientific papers

One-pot synthesis of imidazolines from aldehydes: detailed study about solvents and substrates

Imidazolines were prepared in one-pot operation from aldehydes and diamines through oxidation of aminal intermediates by NBS. This method could be applied to various aromatic and aliphatic aldehydes and N-nonsubstituted and N-monosubstituted 1,2-diamines. Furthermore, it was found that CH2Cl2 could be altered to TBME, a more environmentally friendly solvent, in the reaction using N-nonsubstituted 1,2-diamines. The reaction conditions were very mild and chemoselective.

Facile preparation of 2-imidazolines from aldehydes with tert-butyl hypochlorite

An efficient and high-yield preparation of 2-imidazolines was achieved from aldehydes and ethylenediamines in the presence of tert-butyl hypochlorite. By this method, 1,3-bis(imidazolin-2-yl)benzene and 2,6-bis(imidazolin-2-yl) pyridine, which act as chiral ligands, could be prepared directly from the corresponding dialdehydes in high yields. Georg Thieme Verlag Stuttgart.

Direct oxidative conversion of aldehydes and alcohols to 2-imidazolines and 2-oxazolines using molecular iodine

Aldehydes were converted to the corresponding 2-imidazolines and 2-oxazolines in good yields by the reaction with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate. Moreover, primary alcohols were directly converted to the corresponding 2-imidazolines and 2-oxazolines via aldehydes in one-pot manner with ethylenediamine and aminoethanol, respectively, using molecular iodine and potassium carbonate.

A mild and efficient one-pot synthesis of 2-dihydroimidazoles from aldehydes

The reactions of various aldehydes and 1,2-diamines followed by NXS treatment proceed at 0°C-rt to give the corresponding dihydroimidazoles in high yields. The reaction is mild, and many functional groups such as halogens, nitriles, and esters can exist.

A new protocol for the synthesis of N(1)-unsubstituted 2-substituted 2 imidazolines

Lateral metallation at C-2(α) of 1-tert-butoxycarbonyl-2-methyl-2- imidazoline followed by reaction with a range of C-electrophiles and deprotection with TFA reliably affords N(1)-unsubstituted 2-substituted 2- imidazolines; P- or Se-electrophiles lead to 2-alkenyl-2-imidazolines via Wadsworth-Emmons or selenoxide elimination protocols. (C) 2000 Elsevier Science Ltd.

Imidazoline receptors: Qualitative structure-activity relationships and discovery of tracizoline and benazoline. Two ligands with high affinity and unprecedented selectivity

The observation that all the attempts to characterize imidazoline (I) receptors have been carried out with non-selective or poorly selective ligands prompted us to undertake research aimed at developing selective ligand(s). In previous work using, as a st