260446-54-6Relevant academic research and scientific papers
Calcium-mediated hydrophosphorylation of organic isocyanates with diphenylphosphane oxide
Haerling, Stephan,Greiser, Julia,Al-Shboul, Tareq M. A.,Goerls, Helmar,Krieck, Sven,Westerhausen, Matthias
, p. 1264 - 1273 (2013)
The calcium-mediated addition of diphenylphosphane oxide to organic isocyanates and isothiocyanates yields N-alkyl and N-aryl substituted diphenylphosphorylformamides (E≤O, R≤iPr, tBu, cHex, Ph, C6H4-4-Br, C6H2-2,4,6-Me3, and Naph) and -thioformamides (E≤S, R≤iPr, cHex, Ph, and C6H4-4-Me), respectively, of the type Ph2P(O)-C(E)-N(H)R. All derivatives were characterized by IR and NMR spectroscopy as well as X-ray diffraction experiments. The wavenumbers of the N-H stretching modes are smaller for the thio analogues and N-aryl substituents. In the solid state all formamides and thioformamides form dimers by N-HO-P hydrogen bridges. The P-CCE bonds are significantly elongated compared with the P-CPh distances.
Catalyst- and solvent-free bisphosphinylation of isothiocyanates: A practical method for the synthesis of bisphosphinoylaminomethanes
Wen, Li-Rong,Sun, Yong-Xu,Zhang, Jin-Wei,Guo, Wei-Si,Li, Ming
supporting information, p. 125 - 129 (2018/01/17)
A general and convenient double addition of phosphine oxides to isothiocyanates is described. It is a practically useful protocol for the construction of bisphosphinoylaminomethanes. The reaction can be carried out smoothly under metal- and solvent-free c
