26048-10-2Relevant academic research and scientific papers
Structure and conserved function of iso-branched sphingoid bases from the nematode: Caenorhabditis elegans
Thomas Hannich,Mellal, Denia,Feng, Suihan,Zumbuehl, Andreas,Riezman, Howard
, p. 3676 - 3686 (2017/07/10)
Sphingolipids are bio-active metabolites that show structural diversity among eukaryotes. They are essential for growth of all eukaryotic cells but when produced in an uncontrolled manner can lead to cell death and pathologies including auto-immune reacti
GLYCOSPHINGOLIPIDS FOR USE IN MODULATING IMMUNE RESPONSES
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Page/Page column 62; 63, (2013/08/28)
Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
