260549-56-2Relevant academic research and scientific papers
Discovery and SAR of novel mGluR5 non-competitive antagonists not based on an MPEP chemotype
Rodriguez, Alice L.,Williams, Richard,Zhou, Ya,Lindsley, Stacey R.,Le, Uyen,Grier, Mark D.,David Weaver,Jeffrey Conn,Lindsley, Craig W.
scheme or table, p. 3209 - 3213 (2010/03/31)
This Letter describes the discovery and SAR of three novel series of mGluR5 non-competitive antagonists/negative allosteric modulators (NAMs) not based on manipulation of an MPEP/MTEP chemotype. This work demonstrates fundamentally new mGluR5 NAM chemotypes with submicromolar potencies, and the first example of a mode of pharmacology 'switch' to provide PAMs with a non-MPEP scaffold.
Cathylation of 4,6-dimethyl-2-oxopyridine-3-carbonitrile derivatives leading to the synthesis of furo[2,3-b;4,5-b']dipyridines and novel tricyclic furo[2,3,4-ij][2,7]naphthyridine
Lin, Chyun-Feng,Lin, Yi-Feng,Lo, Yan-Chung,Chen, Kuo-Tung,Su, Tsann-Long
, p. 15 - 26 (2007/10/03)
Cathylation of ethyl 2-(3-cyano-4,6-dimethylpyridine-2-yloxy)acetate afforded a trace amount of new tricyclic furo[2,3,4-ij][2,7]naphthyridine derivative. An attempt was made for an alternate method for the synthesis this new tricyclic ring system. Treatm
