26059-84-7Relevant articles and documents
Benign and efficient synthesis of 2-substituted 4(3H)-quinazolinones mediated by iron(III) chloride hexahydrate in refluxing water
Wang, Guan-Wu,Miao, Chun-Bao,Kang, Hui
, p. 1426 - 1430 (2006)
Condensation of aldehydes with anthranilamide in refluxing water using iron(III) chloride hexahydrate as an oxidiant afforded 2-substituted 4(3H)-quinazolinones in good yields (77-93%). This method provides several advantages such as being environmentally friendly, having a simple work-up procedure, and affording high yields.
Catalyst-free synthesis of quinazolinones by oxidative cyclization under visible light in the absence of additives
Yang, Jiangnan,Xie, Zongbo,Chen, Zhongsheng,Jin, Liang,Li, Qian,Le, Zhanggao
, p. 1496 - 1501 (2021/05/03)
A general metal-free oxidative cyclization route was developed to synthesize quinazolinones under visible light. A series of substituted 2-aminobenzamides were reacted with aldehydes or ketones to produce the desired quinazolinones in good yields. Most importantly, the reaction did not require excess oxidant or high temperatures.
A Metal- and Ligand-Free Synthesis of Quinazolin-4(3H)-ones via a Bu4NI/TBHP-Mediated Oxidative Cleavage of the Olefinic C=C Bond
Gollamudi, P.,Inkollu, B.,Karasala, B. K.,Vidavalur, S.
, p. 1446 - 1454 (2020/10/02)
Abstract: A metal and ligand-free protocol has been developed for the synthesis of quinazolin-4(3H)-ones in moderate to good yields from o-aminobenzamide and alkenes via a Bu4NI/TBHP-mediated oxidative cleavage of the C=C bond in alkenes.
