26062-48-6

Basic information

• Product Name: POLY-L-HISTIDINE HYDROCHLORIDE MW
• Synonyms: polyhistidine;POLY-L-HISTIDINE HYDROCHLORIDE MW;POLY-L-HISTIDINE MOL WT 5000-15000;POLY-L-HISTIDINE, HYDROCHLORIDE*MW 15,00 0-50,000;poly-L-HistidineMW5000-15000;poly-L-histidine chloride
• CAS NO: 26062-48-6
• Molecular Formula: C6H9N3O2
• Molecular Weight: 155.15456
• EINECS: 211-438-9
• Product Categories: Amino Acids;Homopolymers;Polyamino Acids
• Mol File: 26062-48-6.mol
• Article Data: 64

Chemical Properties

• Boiling Point: 458.9°Cat760mmHg
• Flash Point: 231.3°C
• Appearance: /
• Density: 1.423g/cm³
• Vapor Pressure: 3.25E-09mmHg at 25°C
• Refractive Index: 1.614
• Storage Temp.: −20°C
• CAS DataBase Reference: POLY-L-HISTIDINE HYDROCHLORIDE MW(CAS DataBase Reference)
• NIST Chemistry Reference: POLY-L-HISTIDINE HYDROCHLORIDE MW(26062-48-6)
• EPA Substance Registry System: POLY-L-HISTIDINE HYDROCHLORIDE MW(26062-48-6)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 26062-48-6(Hazardous Substances Data)

Usage

Description

Poly-L-histidine hydrochloride MW is an amphoteric compound characterized by the presence of an imidazole ring in its structure, which allows for protonation and deprotonation. This unique property makes it versatile in various applications across different industries.

Uses

Used in Nanotechnology Industry:
Poly-L-histidine hydrochloride MW is used as a polycation for the dispersion of multi-wall carbon nanotubes (MWCNTs). Its cationic nature helps in the dispersion process, enhancing the properties and potential applications of MWCNTs in various fields.
Used in Virology Research:
Poly-L-histidine hydrochloride MW is used as a polyionic compound to investigate its ability to rupture extracellular enveloped virus membranes. This application is crucial in understanding the interactions between viruses and host cells, as well as in the development of antiviral strategies.
Used in Prion Disease Research:
Poly-L-histidine hydrochloride MW is used in screening its anti-prion activity in cell-based and in vivo anti-prion assays. This application is significant in the study of prion diseases, which are a group of neurodegenerative disorders, and in the development of potential treatments for these conditions.

Biochem/physiol Actions

Poly-L-histidine (Phis) copolymers are biocompatible, pH responsive and are less toxic. It exhibits endolysosomal escape funcationality. The copolymer of Phis with poly(ethylene glycol)?poly(d,l-lactide) (PEG-PLA) is effective in delivering doxorubicin. pH sensitive poly(l-histidine) copolymer micelles have application in delivering anticancer drugs in acidic microenvironment.

InChI:InChI=1/C6H9N3O2/c7-5(6(10)11)1-4-2-8-3-9-4/h2-3,5H,1,7H2,(H,8,9)(H,10,11)/t5-/m0/s1

Upstream product

• 1499-46-3 L-histidine methyl ester 
• 74419-67-3 2-Carboxy-L-histidine Hydrochloride 
• 58942-05-5 5-[(4-imidazolyl)methyl]hydantoin 
• 4998-57-6 His 
• 1604-44-0 N-α-trifluoroacetyl-L-histidine methyl ester 
• 645-35-2 L-histidine monohydrochloride 
• 2497-02-1 N-acetyl-L-histidine 
• 108-24-7 acetic anhydride 
• 71-00-1 L-histidine 
• 14056-33-8 2-(benzoylamino)-3-imidazol-4-ylpropanoic acid 
• 10101-30-1 N-acetylhistidine 
• 71-00-1 L-histidine 

Downstream Products

• 59981-63-4 (6S)-4,5,6,7-tetrahydro-1H-imidazo<4,5-c>pyridine-6-carboxylic acid 
• 14403-45-3 (S)-3-(5-imidazolyl)-2-hydroxypropionic acid 
• 645-14-7 (3H-imidazol-4-yl)acetaldehyde 
• 77504-36-0 2-amino-3-((4-((S)-2-amino-2-carboxyethyl)-1H-imidazol-2-yl)thio)propionic acid 
• 56-86-0 L-glutamic acid 
• 51-45-6 histamine 
• 4467-54-3 D-histidine methyl ester dihydrochloride 
• 67391-96-2 L-histidine methacrylamide 

Relevant articles and documents

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Reduction potential of histidine free radicals: A pulse radiolysis study

The technique of pulse radiolysis has been used to demonstrate that all histidine free radicals (designated His.+) produced by oxidation of histidine by Br2.- radical anions can oxidise the water soluble vitamin E analogue, Trolox C (k = 1.0 ± 0.2 × 109 dm3 mol-1 s-1 at pH 6.95). It has also been shown that His.+ radicals can react with tryptophan in electron transfer equilibria involving both His.+ and Trp.+ species over the pH range 6.4-9.0. The ΔE values [E(Trp.+/Trp) - E(His.+/His)] range from -140 to -161 mV and indicate an E7(His.+/His) value of 1170 mV [based on E7(Trp.+/Trp) = 1015 mV at pH 7]. The effect of pH on E(His.+/His) was accounted for by assuming that His.+ can deprotonate to yield a bi-allylic free radical, designated His (-H+).. The pKa for this dissociation was estimated to be in the range 5-7. The implications of the relatively high reduction potential for His.+ in its possible participation in the mechanism of action of non-heme metalloenzymes is discussed.

Chromatographic Resolution of α-Amino Acids by (R)-(3,3'-Halogen Substituted-1,1'-binaphthyl)-20-crown-6 Stationary Phase in HPLC

Three new chiral stationary phases (CSPs) for high-performance liquid chromatography were prepared from R-(3,3'-halogen substituted-1,1'-binaphthyl)-20-crown-6 (halogen = Cl, Br and I). The experimental results showed that R-(3,3'-dibromo-1,1'-binaphthyl)-20-crown-6 (CSP-1) possesses more prominent enantioselectivity than the two other halogen-substituted crown ether derivatives. All twenty-one α-amino acids have different degrees of separation on R-(3,3'-dibromo-1,1'-binaphthyl)-20-crown-6-based CSP-1 at room temperature. The enantioselectivity of CSP-1 is also better than those of some commercial R-(1,1'-binaphthyl)-20-crown-6 derivatives. Both the separation factors (α) and the resolution (Rs) are better than those of commercial crown ether-based CSPs [CROWNPAK CR(+) from Daicel] under the same conditions for asparagine, threonine, proline, arginine, serine, histidine and valine, which cannot be separated by commercial CR(+). This study proves the commercial usefulness of the R-(3,3'-dibromo-1,1'-binaphthyl)-20-crown-6 chiral stationary phase.

INSULIN PREPARATIONS CONTAINING METHIONINE

The invention relates to an aqueous pharmaceutical formulation having insulin, an insulin analog, or an insulin derivative, and methionine; and to the production thereof, to the use thereof for treating diabetes mellitus, and to a medication for treating diabetes mellitus.