26063-96-7

Basic information

• Product Name: 3-Isomangostin hydrate
• Synonyms: 3-Isomangostin hydrate;3,4-Dihydro-5,9-dihydroxy-11-(3-hydroxy-3-methylbutyl)-10-methoxy-2,2-dimethyl-2H,12H-pyrano[2,3-a]xanthen-12-one
• CAS NO: 26063-96-7
• Molecular Formula: C24H28O7
• Molecular Weight: 428.47492
• Mol File: 26063-96-7.mol
• Article Data: 5

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-Isomangostin hydrate(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Isomangostin hydrate(26063-96-7)
• EPA Substance Registry System: 3-Isomangostin hydrate(26063-96-7)

Safety Data

• Hazardous Substances Data: 26063-96-7(Hazardous Substances Data)

Usage

General Description

3-Isomangostin hydrate is a chemical compound that belongs to the class of xanthones, which are organic compounds with a heterocyclic ring. 3-Isomangostin hydrate is naturally occurring and has been isolated from various plants, including Garcinia mangostana L., also known as mangosteen. 3-Isomangostin hydrate has been found to possess various biological activities, including antioxidant, anti-inflammatory, and anticancer properties. It has also shown potential in inhibiting the growth of certain tumor cells and inducing cell death. The compound has been the subject of research for its potential therapeutic applications in medicine and is of interest for its natural origin and medicinal properties.

Upstream product

• 6147-11-1 α-mangostin 
• 19275-46-8 3-isomangostin 
• 64-18-6 formic acid 

Relevant articles and documents

Modified tetra-oxygenated xanthones analogues as anti-MRSA and P. aeruginosa agent and their synergism with vancomycin

Five isolated xanthones from the C. cochinchinense and G. mangostana were evaluated and tested for antibacterial activities. Isolated 4 and 5 exhibited potent anti-MRSA and P. aeruginosa activity, but showed poor pharmacokinetic properties via ADMET prediction. It led us to improve pharmacokinetic properties of 4 and 5 by partially modifying them in acidic condition yielding fourteen analogues. It was found that analogues 4b, 4d and 5b possessed proper pharmacokinetic properties, while only 4b exhibited the best anti-MRSA and P. aeruginosa activity. The SEM results indicated that 4b may interact with or damage the cell wall of MRSA and P. aeruginosa. Moreover, a combination of 4b and vancomycin exhibits synergistic effect against both MRSA and P. aeruginosa at MIC value of 4.98 (MIC = 18.75 μg/mL for 4b) and 9.52 μg/mL (MIC = 75 μg/mL for 4b), respectively.

Chemistry of α-mangostin. Studies on the semisynthesis of minor xanthones from Garcinia mangostana

α-Mangostin is the major prenylated xanthone from Garcinia mangostana and it has been used also in recent times as starting material for the semisynthetic preparation of various biologically active derivatives. Its structure is characterised by the presence of few functional groups amenable to chemical manipulations, but present in the molecule in multiple instances (three phenolic hydroxyl groups, two prenyl chains and two unsubstituted aromatic carbons). This study represents a first approach to the systematic investigation of the reactivity of α-mangostin and describes the semisynthesis of some minor xanthones isolated from G. mangostana.

Acid-catalysed Cyclisations of Xanthones: Structure of a New Xanthone from Garcinia mangostana Linn.

Acid-catalysed cyclisations of hydroxyprenylxanthone metabolites, mangostin (I) and normangostin (VI) from Garcinia mangostana Linn. have been studied.A new xanthone garcinone-E has also been isolated from G.mangostana and the structure (IX) is established on the basis of its cyclised dihydropyranoxanthone derivative (X).