26072-85-5

Basic information

• Product Name: 1-[(2-hydroxyethyl)amino]-3-methoxypropan-2-ol
• CAS NO: 26072-85-5
• Molecular Formula: C₆H₁₅NO₃
• Molecular Weight: 149.1882
• Mol File: 26072-85-5.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 279.7°C at 760 mmHg
• Flash Point: 122.9°C
• Density: 1.079g/cm³
• Vapor Pressure: 0.000478mmHg at 25°C
• Refractive Index: 1.465
• CAS DataBase Reference: 1-[(2-hydroxyethyl)amino]-3-methoxypropan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[(2-hydroxyethyl)amino]-3-methoxypropan-2-ol(26072-85-5)
• EPA Substance Registry System: 1-[(2-hydroxyethyl)amino]-3-methoxypropan-2-ol(26072-85-5)

Safety Data

• Hazardous Substances Data: 26072-85-5(Hazardous Substances Data)

Usage

Type of compound

Synthetic

Classification

Selective alpha-1 adrenergic agonist

Primary use

Vasopressor medication for treating low blood pressure and shock

Mechanism of action

Stimulates alpha-1 adrenergic receptors in blood vessels, causing vasoconstriction and increased peripheral vascular resistance, which raises blood pressure

Administration

Intravenous, commonly in hospital settings

Importance

Vital drug in the management of hypotensive emergencies

Chemical structure

Consists of a hydroxyethylamine group, a methoxy group, and a propan-2-ol moiety, which contribute to its pharmacological actions

Upstream product

• 930-37-0 glycidyl methyl ether 
• 141-43-5 ethanolamine 

Relevant articles and documents

Copper(I) chloride-catalyzed three-component coupling reaction of primary amines with electrophiles and α-halogen-substituted allylsilanes to form unsymmetrical tertiary amines

Tertiary amines with three different substituents, in one of which a vinylsilane functionality was included, were straightforwardly formed by the copper(I) chloride-catalyzed tandem reaction of primary amines, α-halogen-substituted allylsilanes, and electrophiles such as electron-deficient olefins, alkyl halides, alkyl tosylates, or epoxides. In the case using electron-deficient olefins as the electrophile, the addition of chloroacetone to the reaction system afforded the three-component coupling reaction more effectively. The addition of trimethyl borate as a co-catalyst improved the yields of the three-component coupling products in the reaction using alkyl halides, alkyl tosylates, or epoxides as the electrophiles, although the reaction times were lengthened.