26072-85-5

Usage

Type of compound

Synthetic

Classification

Selective alpha-1 adrenergic agonist

Primary use

Vasopressor medication for treating low blood pressure and shock

Mechanism of action

Stimulates alpha-1 adrenergic receptors in blood vessels, causing vasoconstriction and increased peripheral vascular resistance, which raises blood pressure

Administration

Intravenous, commonly in hospital settings

Importance

Vital drug in the management of hypotensive emergencies

Chemical structure

Consists of a hydroxyethylamine group, a methoxy group, and a propan-2-ol moiety, which contribute to its pharmacological actions

Upstream product

• 930-37-0 glycidyl methyl ether 
• 141-43-5 ethanolamine 

Relevant academic research and scientific papers

Copper(I) chloride-catalyzed three-component coupling reaction of primary amines with electrophiles and α-halogen-substituted allylsilanes to form unsymmetrical tertiary amines

Tertiary amines with three different substituents, in one of which a vinylsilane functionality was included, were straightforwardly formed by the copper(I) chloride-catalyzed tandem reaction of primary amines, α-halogen-substituted allylsilanes, and electrophiles such as electron-deficient olefins, alkyl halides, alkyl tosylates, or epoxides. In the case using electron-deficient olefins as the electrophile, the addition of chloroacetone to the reaction system afforded the three-component coupling reaction more effectively. The addition of trimethyl borate as a co-catalyst improved the yields of the three-component coupling products in the reaction using alkyl halides, alkyl tosylates, or epoxides as the electrophiles, although the reaction times were lengthened.

Amine derivative and dermatologic preparation containing the same

The present invention relates to an amine derivative represented by the following general formula (I) or (II): STR1 wherein R1 means a heteroatom-containing C1 -C40 hydrocarbon group which may have a ring structure, or the