930-37-0

Basic information

• Product Name: GLYCIDYL METHYL ETHER
• Synonyms: GLYCIDYL METHYL ETHER;1,2-EPOXY-3-METHOXYPROPANE;(methoxymethyl)-oxiran;(Methoxymethyl)oxirane;(methoxymethyl)-Oxirane;1,2-epoxy-3-methoxy-propan;2-(Methoxymethyl)oxirane;3-Methoxy-1,2-epoxypropane
• CAS NO: 930-37-0
• Molecular Formula: C₄H₈O₂
• Molecular Weight: 88.11
• EINECS: 213-216-7
• Product Categories: Oxiranes;Simple 3-Membered Ring Compounds
• Mol File: 930-37-0.mol
• Article Data: 20

Chemical Properties

• Boiling Point: 110°C
• Flash Point: 24°C
• Appearance: /
• Density: 0,98 g/cm3
• Refractive Index: 1.4080-1.4140
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Toluene (Slightly)
• CAS DataBase Reference: GLYCIDYL METHYL ETHER(CAS DataBase Reference)
• NIST Chemistry Reference: GLYCIDYL METHYL ETHER(930-37-0)
• EPA Substance Registry System: GLYCIDYL METHYL ETHER(930-37-0)

Safety Data

• Statements: 10
• Safety Statements: 16
• RIDADR: 3271
• RTECS: TZ3530000
• HazardClass: 3.1
• PackingGroup: II
• Hazardous Substances Data: 930-37-0(Hazardous Substances Data)

Usage

Uses

2-(Methoxymethyl)oxirane is used in the fixation of biological tissues or in collagen bioprosthetic fixation processes.

General Description

Clear colorless liquid.

Air & Water Reactions

Highly flammable. May be sensitive to exposure to air(peroxide formation). . Water soluble.

Reactivity Profile

GLYCIDYL METHYL ETHER, an ether can act as a base. They form salts with strong acids and addition complexes with Lewis acids. The complex between diethyl ether and boron trifluoride is an example. Ethers may react violently with strong oxidizing agents. In other reactions, which typically involve the breaking of the carbon-oxygen bond, ethers are relatively inert.

Fire Hazard

GLYCIDYL METHYL ETHER is flammable.

InChI:InChI=1/C4H8O2/c1-5-2-4-3-6-4/h4H,2-3H2,1H3

Upstream product

• 67-56-1 methanol 
• 3132-64-7 1,2-Epoxy-3-bromopropane 
• 186581-53-3 diazomethane 
• 107-31-3 Methyl formate 
• 106-92-3 Allyl glycidyl ether 
• 33100-27-5 15-crown-5 
• 74-88-4 methyl iodide 
• 106-89-8 epichlorohydrin 
• 142-28-9 1,3-Dichloropropane 
• 627-30-5 1-chloro-3-hydroxypropane 
• 227945-00-8 diethyl 2-amino-6-[(hydroxycarbamoyl)-methyl]-azulene-1,3-dicarboxylate sodium 
• 124-41-4 sodium methylate 
• 627-40-7 methylallylether 
• 4151-97-7 1-chloro-3-methoxypropan-2-ol 

Downstream Products

• 53146-34-2 1-isopropoxy-3-methoxy-2-propanol 
• 93372-65-7 2-hydroxy-3-methoxypropylamine 
• 54469-44-2 N-(2-hydroxy-3-methoxypropyl)piperazine 
• 92037-01-9 N,N'-bis(2-hydroxy-3-methoxypropyl)piperazine 
• 40492-31-7 4-methoxymethyl-1,3-dioxolan-2-one 
• 187737-37-7 propene 
• 115-10-6 Dimethyl ether 
• 62498-14-0 trans-1,3-bis(perfluoro-tert-butyl)propene 
• 39504-13-7 3-hydroxy-3-(phenylthio)propyl methyl ether 
• 123295-65-8 2-acetoxy-3-(phenylthio)propyl methyl ether 
• 123295-64-7 2-benzoyloxy-3-(phenylthio)propyl methyl ether 
• 121485-55-0 Butyl-[4-methoxymethyl-3-phenyl-oxazolidin-(2Z)-ylidene]-amine 
• 121485-60-7 Butyl-[5-methoxymethyl-3-phenyl-oxazolidin-(2Z)-ylidene]-amine 
• 69644-94-6 1-phenyl-5-hydroxy-1,2-diaza-3,7-dioxa-1-octene 1-oxide 

Relevant articles and documents

Preparation method of nifuratel related substance A

The invention provides a preparation method of a nifuratel related substance A. The preparation method comprises the following steps: (1) reacting sodium methoxide with epichlorohydrin to prepare 2-(methoxymethyl)-oxetane; (2) dropwise adding the 2-(methoxymethyl)-oxygen heterocyclic propane into hydrazine hydrate, so as to prepare 3-methoxy-2-hydroxyl-propyl hydrazine; and (3) adding diethyl carbonate into the 3-methoxy-2-hydroxy-propyl hydrazine to prepare the nifuratel related substance A, namely, the N-amino-5-methoxymethyl-2-oxazolidinone. According to the preparation method of the nifuratel related substance A disclosed by the invention, the nifuratel related substance A can be conveniently and quickly obtained, and the obtained nifuratel related substance A is high in yield and good in purity.

Olefin epoxidation with ionic liquid catalysts formed by supramolecular interactions

This work demonstrated that the specific ionic liquids (ILs) have been designed via the supramolecular complexation between 18-crown-6 (CE) and ammonium peroxoniobate (NH4-Nb). The resultant ILs have been characterized by elemental analysis, FT-IR, Raman, NMR, DSC, conductivity measurement and MALDI-TOF, etc. The IL (CE-1) consisting of CE and ammonium peroxoniobate can be further coordinated with GLY to generate a new IL (CE-2), which showed both high catalytic activity in epoxidation with H2O2 and good recyclability. The characterization of 93Nb NMR spectra revealed that the peroxoniobate anions has demonstrated a structural evolution in the presence of hydrogen peroxide, in which Nb[dbnd]O species can be easily oxidized into the catalytically active niobium?peroxo species. Especially, the supramolecular complexation can provide suitable hydrophobicity, which ensured that the hydrophobic olefins and allylic alcohols were easily accessible to the catalytically active anions, and thus facilitated the epoxidation reaction. Notably, the supramolecular IL catalysts in this work exhibited a huge advantage of the easy availability, as compared with the previously reported peroxoniobate-based ILs. As far as we know, this is the first example of the highly selective epoxidation of olefins and allylic alcohols by using supramolecular ILs as catalysts.

Rational design 2-hydroxypropylphosphonium salts as cancer cell mitochondria-targeted vectors: Synthesis, structure, and biological properties

It has been shown for a wide range of epoxy compounds that their interaction with triphenylphosphonium triflate occurs with a high chemoselectivity and leads to the formation of (2-hydroxypropyl)triphenylphosphonium triflates 3 substituted in the 3-position with an alkoxy, alkylcarboxyl group, or halogen, which were isolated in a high yield. Using the methodology for the disclosure of epichlorohydrin with alcohols in the presence of boron trifluoride ether-ate, followed by the substitution of iodine for chlorine and treatment with triphenylphosphine, 2-hydroxypropyltriphenylphosphonium iodides 4 were also obtained. The molecular and supramolec-ular structure of the obtained phosphonium salts was established, and their high antitumor activity was revealed in relation to duodenal adenocarcinoma. The formation of liposomal systems based on phosphonium salt 3 and L-α-phosphatidylcholine (PC) was employed for improving the bioavailabil-ity and reducing the toxicity. They were produced by the thin film rehydration method and exhibited cytotoxic properties. This rational design of phosphonium salts 3 and 4 has promising potential of new vectors for targeted delivery into mitochondria of tumor cells.