260782-06-7

Upstream product

• 284676-39-7 (+)-(S)-5-fluoromethyl-3,3-dimethylpyrrolidin-2-one 
• 829-84-5 dicyclohexylphosphane 
• 260781-95-1 (+)-(S)-5-[(4-diphenylphosphino)methyl]-3,3-dimethylpyrrolidin-2-one 
• 163756-60-3 (+)-(S)-3,3-dimethyl-5-{[(4-methylphenyl)sulfonyloxy]methyl}pyrrolidin-2-one 
• 156088-46-9 (5S)-3,3-dimethyl-5-hydroxymethylpyrrolidin-2-one 

Relevant academic research and scientific papers

Approach to enantioselective conjugate addition of organocopper reagents to cycloalkenones by the aid of chiral lactam bearing phosphine group

The chiral lactam-phosphine ligand and copper salt mediated asymmetric conjugate addition reaction of butylmagnesium chloride and diethylzinc with cycloalkenones afforded the addition products in moderate selectivity. Among phosphines examined, 5-[(diphenylphosphiao)methyl]-3,3-dimethylpyrrolidin-2- one 5 gave rise to moderate enantioselectivity and high yield. (C) 2000 Elsevier Science Ltd.