260784-18-7 Usage
Uses
Used in Pharmaceutical Industry:
5-(2-carboxymethoxy-5-methoxybenzylidene)-4-oxo-2-thioxothiazolidine is used as a key intermediate in the synthesis of new drugs for various therapeutic applications. Its unique chemical structure allows for the development of novel compounds with potential biological activities.
Used in Biological Activities:
In the field of biological activities, 5-(2-carboxymethoxy-5-methoxybenzylidene)-4-oxo-2-thioxothiazolidine is used as a starting material for the preparation of a new series of 5-[[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2-thioxothiazolidine derivatives. These derivatives exhibit significant aldose reductase inhibitory activity, which is important for the development of treatments for various diseases, such as diabetes and its complications.
Used in Aldose Reductase Inhibitors:
5-(2-carboxymethoxy-5-methoxybenzylidene)-4-oxo-2-thioxothiazolidine is used as a building block for the development of aldose reductase inhibitors. These inhibitors play a crucial role in managing the progression of diabetic complications by reducing the harmful effects of polyol pathway flux.
Check Digit Verification of cas no
The CAS Registry Mumber 260784-18-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,6,0,7,8 and 4 respectively; the second part has 2 digits, 1 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 260784-18:
(8*2)+(7*6)+(6*0)+(5*7)+(4*8)+(3*4)+(2*1)+(1*8)=147
147 % 10 = 7
So 260784-18-7 is a valid CAS Registry Number.
260784-18-7Relevant academic research and scientific papers
Murata, Makoto,Fujitani, Buichi,Mizuta, Hiroyuki
, p. 1061 - 1070 (1999)
A new series of 5-[[2-(ω-carboxyalkoxy)aryl]methylene]-4-oxo-2- thioxothiazolidine derivatives was synthesized and evaluated for their potency as aldose reductase inhibitors (ARIs). Their activities were examined in terms of their inhibitory effect on rat lens aldose reductase in vitro and in terms of the preventive effect on sorbitol accumulation in the sciatic nerve of streptozotocin (STZ)-induced diabetic rats in vivo. Of these compounds, some of the naphthylmethylene thiazolidine derivatives were comparable to Zenarestat in the inhibitory potency in vitro and in vivo. In particular, compound 30 was 1.5 times more potent than Zenarestat in the in vivo activity, and had an adequate potency for clinical development.
