76322-07-1

Basic information

• Product Name: ethyl (2-formyl-4-methoxyphenoxy)acetate
• Synonyms: acetic acid, 2-(2-formyl-4-methoxyphenoxy)-, ethyl ester; Ethyl (2-formyl-4-methoxyphenoxy)acetate
• CAS NO: 76322-07-1
• Molecular Formula: C₁₂H₁₄O₅
• Molecular Weight: 238.2366
• Mol File: 76322-07-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 372°C at 760 mmHg
• Flash Point: 203°C
• Density: 1.178g/cm³
• Vapor Pressure: 9.89E-06mmHg at 25°C
• Refractive Index: 1.526
• CAS DataBase Reference: ethyl (2-formyl-4-methoxyphenoxy)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl (2-formyl-4-methoxyphenoxy)acetate(76322-07-1)
• EPA Substance Registry System: ethyl (2-formyl-4-methoxyphenoxy)acetate(76322-07-1)

Safety Data

• Hazardous Substances Data: 76322-07-1(Hazardous Substances Data)

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 105-39-5 chloroacetic acid ethyl ester 
• 150-76-5 4-methoxy-phenol 
• 105-36-2 ethyl bromoacetate 

Downstream Products

• 76322-12-8 (2-ethoxycarbonylmethoxy-5-methoxyphenyl)hydroxyacetonitrile 
• 24589-93-3 2-(2-formyl-4-methoxyphenoxy)acetic acid 
• 10242-08-7 5-methoxybenzofuran-2-carboxylic acid 
• 860744-04-3 (2',4'-dihydroxy-5-methoxy-α'-oxo-bibenzyl-2-yloxy)-acetic acid 
• 76322-20-8 ethyl(2-ethoxycarbonylmethoxy-5-methoxyphenyl)acetate 
• 858847-30-0 (2-Carboxymethoxy-5-methoxy-phenyl)-acetic acid 
• 76322-25-3 6-methoxychroman-3-one 
• 260784-18-7 5-(2-carboxymethoxy-5-methoxybenzylidene)-4-oxo-2-thioxothiazolidine 
• 50551-56-9 ethyl 5-methoxybenzofuran-2-carboxylate 

Relevant articles and documents

Synthesis and biological evaluation of novel shikonin-benzo[b]furan derivatives as tubulin polymerization inhibitors targeting the colchicine binding site

A novel series of shikonin-benzo[b]furan derivatives were designed and synthesized as tubulin polymerization inhibitors, and their biological activities were evaluated. Most compounds revealed the comparable anti-proliferation activities against the cancer cell lines to that of shikonin and simultaneously low cytotoxicity to non-cancer cells. Among them, compound 6c displayed powerful anti-cancer activity with the IC50 value of 0.18 μM against HT29 cells, which was significantly better than that of the reference drugs shikonin and CA-4. What's more, 6c could inhibit tubulin polymerization and compete with [3H] colchicine in binding to tubulin. Further biological studies depicted that 6c can induce cell apoptosis and cell mitochondria depolarize, regulate the expression of apoptosis related proteins in HT29 cells. Besides, 6c actuated the HT29 cell cycle arrest at G2/M phase, and influenced the expression of the cell-cycle related protein. Moreover, 6c displayed potent inhibition on cell migration and tube formation that contributes to the antiangiogenesis. These results prompt us to consider 6c as a potential tubulin polymerization inhibitor and is worthy for further study.

BENZOFURAN AND BENZOTHIOPHENE-2-CARBOXYLIC ACID AMIDE DERIVATIVES

The present invention relates to compounds of formula I wherein X, A and R1 to R4 are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.

Preparation of synthetic rotenoids

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