260790-85-0

Upstream product

• 103357-81-9 5-O-trifluoromethanesulfonyl-1,2-O-isopropylidene-α-D-glucofuranurono-6,3-lactone 
• 3067-56-9 D-glucurono-3,6-lactone acetonide 
• 260790-70-3 3-O-acetyl-5-azido-5-deoxy-1,2-O-isopropylidene-6-p-tolylsulfonyl-β-L-idofuranose 
• 260790-71-4 3-O-acetyl-5,6-diazido-5,6-dideoxy-1,2-O-isopropylidene-β-L-idofuranose 
• 260790-73-6 5,6-diazido-5,6-dideoxy-1,2-O-isopropylidene-β-L-idofuranose 
• 260790-75-8 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-β-L-idofuranose 
• 130619-55-5 5-azido-5-deoxy-1,2-O-isopropylidene-β-L-idofuranose 
• 66592-80-1 5-azido-5-deoxy-1,2-O-isopropylidene-β-L-idurono-3,6-lactone 
• 260790-79-2 5,6-diamino-5,6-dideoxy-1,2-O-isopropylidene-β-L-idofuranose 5,6-(cyclic urea) 

Relevant academic research and scientific papers

Generalized Anomeric Effect in Action: Synthesis and Evaluation of Stable Reducing Indolizidine Glycomimetics as Glycosidase Inhibitors

A series of aminoketalic castanospermine analogues incorporating a stereoelectronically anchored axial hydroxy group at the pseudoanomeric stereocenter (C-5) have been synthesized to satisfy the need for glucosidase inhibitors that are highly selective for α-glucosidases. The polyhydroxylated bicyclic system was built from readily available hexofuranose derivatives through a synthetic scheme that involved (i) the construction of a five-membered cyclic (thio)carbamate or (thio)urea moiety at the nonreducing end and (ii) the intramolecular nucleophilic addition of the heterocyclic thiocarbamic nitrogen atom to the masked aldehyde group of the monosaccharide. A biological screening of the resulting reducing 2-oxa- and 2-azaindolizidines against several glycosidase enzymes is reported.