3067-56-9

Basic information

• Product Name: (3aR,6R,7aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one
• CAS NO: 3067-56-9
• Molecular Weight: 216.191
• Mol File: 3067-56-9.mol

Chemical Properties

• CAS DataBase Reference: (3aR,6R,7aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one(CAS DataBase Reference)
• NIST Chemistry Reference: (3aR,6R,7aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one(3067-56-9)
• EPA Substance Registry System: (3aR,6R,7aR)-6-Hydroxy-2,2-dimethyl-tetrahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxol-5-one(3067-56-9)

Safety Data

• Hazardous Substances Data: 3067-56-9(Hazardous Substances Data)

Upstream product

• 32449-92-6 D-glucurono-6,3-lactone 
• 5206-40-6 5-O-acetyl-1,2-O-isopropylidene-β-L-idofuranurono-6,3-lactone 
• 63-29-6 D-glucurono-6,3-lactone 
• 67-64-1 acetone 
• 14362-29-9 α-D-glucurono-γ-lactone 
• 18549-40-1 1,2-O-isopropylidene-α-D-glucofuranose 
• 63-29-6 L-glucurono-3,6-lactone 
• 3067-56-9 isopropylidene glucuronolactone 
• 575-64-4 D-mannofuranurono-6,3-lactone 
• 5111-13-7 (1S,3R,4R,5S,8S)-8-benzyloxy-7-keto-3,4-isopropylidenedioxy-2,6-dioxabicyclo[3.3.0]octane 
• 2671-19-4 O¹,O²-isopropylidene-α-D-glucofuranuronic acid 
• 15397-08-7 D-glycero-D-galacto-heptono-1,4-lactone 

Downstream Products

• 50767-75-4 methyl 3,5-O-benzylidene-1,2-O-isopropylidene-α-D-glucofuranuronate 
• 55263-78-0 1,2-O-isopropylidene-5-O-toluene-p-sulphonyl-α-D-glucofuranurono-6,3-lactone 
• 138610-59-0 N-(p-methoxybenzyl)-1,2-isopropylidene-D-glucofuranuronamide 
• 170872-96-5 (+)-1,2-O-Isopropylidene-5-O-(phenoxythiocarbonyl)-α-D-glucurono-6,3-lactone 
• 183371-82-6 (3aR,3bS,5R,6S,6aR,7aR)-2,2-Dimethyl-5-phenyl-hexahydro-furo[2',3':4,5]furo[2,3-d][1,3]dioxole-5,6-diol 
• 5111-13-7 (1S,3R,4R,5S,8S)-8-benzyloxy-7-keto-3,4-isopropylidenedioxy-2,6-dioxabicyclo[3.3.0]octane 
• 6984-47-0 C₁₆H₁₆O₇ 
• 170872-98-7 Methyl 1,2-O-isopropylidene-5-O-(phenoxythiocarbonyl)-α-D-glucuronate 
• 170872-99-8 Methyl 3-O-(tert-butyldimethylsilyl)-1,2-O-isopropylidene-5-O-(phenoxythiocarbonyl)-α-D-glucuronate 
• 170873-34-4 10,11-Anhydro-5,7-dideoxy-1,2-O-isopropylidene-9-O-(methoxymethyl)-7-C-<<(2-nitrophenyl)seleno>methyl>-β-L-ido-L-ido-undecofuranose 
• 170873-38-8 (3aR,5R,6S,6aR)-5-[(2R,3S)-2-Hydroxy-3-((2R,3R,4S)-4-hydroxy-3-methoxymethoxy-tetrahydro-furan-2-yl)-4-(2-nitro-phenylselanyl)-butyl]-2,2-dimethyl-tetrahydro-furo[2,3-d][1,3]dioxol-6-ol 
• 170873-39-9 3,6,10-Tri-O-acetyl-8,11-anhydro-5,7-dideoxy-O-1,2-isopropylidene-9-O-(methoxymethyl)-7-C-<<(2-nitrophenyl)seleno>methyl>-β-L-ido-L-ido-undecofuranose 
• 170873-33-3 3-O-(tert-Butyldimethylsilyl)-10-chloro-5,7,10-trideoxy-6,8,11-tri-O-(triethylsilyl)-1,2-O-isopropylidene-9-O-(methoxymethyl)-7-C-<<(2-nitrophenyl)seleno>methyl>-α-D-gluco-L-ido-undecofuranose 
• 28235-34-9 2,3,4-tri-O-acetyl-1,6-anhydro-β-L-idopyranose 

Relevant articles and documents

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The invention relates to the technical field of organic synthesis, in particular to a method for preparing an eribulin dehydroxylation intermediate by a one-pot method, which comprises the following steps of in an organic solvent, taking a compound I as a raw material, carrying out oxidation-reduction reaction on the compound I, a reducing agent, a catalyst and alkali, and separating and purifying reaction liquid to obtain a compound as shown in a formula II, namely the eribulin dehydroxylation intermediate. According to the method disclosed by the invention, sulfonyl chloride, Pd/C, iodine elementary substance and pyridine which are not green and are high in price are not used, but cheap and green reagents are adopted for replacement, so that the greenness, the economical efficiency and the safety of the reaction are remarkably improved. The reaction efficiency is greatly improved and the reaction cost is reduced by shortening the reaction steps and the reaction time.

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