26087-09-2Relevant academic research and scientific papers
Ph3P/I2-Mediated Synthesis of 3-Aryl-Substituted and 3,4-Disubstituted Coumarins
Phakhodee, Wong,Duangkamol, Chuthamat,Yamano, Dolnapa,Pattarawarapan, Mookda
, p. 825 - 830 (2017)
Ph3P/I2-Et3N-mediated one-pot two-step esterification-cyclization toward 3-aryl coumarins and 3-aryl-4-methylcoumarins is reported. The reaction of a variety of aryl acetic acids containing steric or reactive group with 2-
A novel synthesis of 3-aryl coumarins and evaluation of their antioxidant and lipoxygenase inhibitory activity
Roussaki, Marina,Kontogiorgis, Christos A.,Hadjipavlou-Litina, Dimitra,Hamilakis, Stylianos,Detsi, Anastasia
experimental part, p. 3889 - 3892 (2010/09/03)
A series of coumarin analogues bearing a substituted phenyl ring on position 3 were synthesized via a novel methodology, through an intermolecular condensation reaction of 2-hydroxyacetophenones and 2-hydroxybenzaldehyde, with imidazolyl phenylacetic acid active intermediates. The in vitro antioxidant activity of the synthesized compounds was evaluated using two different antioxidant assays (radical scavenging ability of DPPH stable free radical and inhibition of lipid peroxidation induced by the thermal free radical AAPH). Moreover, the ability of the compounds to inhibit soybean lipoxygenase was determined as an indication of potential anti-inflammatory activity.
SYNTHESIS OF 3-ARYLCOUMARINS, 2-AROYLBENZOFURANS AND 3-ARYL-2H-1,4-BENZOXAZINES UNDER PHASE-TRANSFER CATALYSIS CONDITIONS
Sabitha, G.,Rao, A. V. Subba
, p. 341 - 354 (2007/10/02)
The synthesis of 3-arylcoumarins, 2-aroylbenzofurans and 3-aryl-2H-1,4-benzoxazines under phase transfer catalysis conditions is described.
