2609-10-1

Usage

InChI:InChI=1/C5H10N2O3/c6-5(10)7-3-1-2-4(8)9/h1-3H2,(H,8,9)(H3,6,7,10)/p-1

Upstream product

• 60285-30-5 4-(3-(3-carboxypropyl)-1-nitrosoureido)butanoic acid 
• 57-13-6 urea 
• 56-12-2 4-amino-n-butyric acid 
• 590-28-3 potassium cyanate 
• 7256-00-0 4-[3-(3-methoxycarbonylpropyl)thioureido]butyric acid 
• 13026-95-4 4,4'-(carbonylbis(azanediyl))dibutyric acid 
• 75548-99-1 tetrahydro-2H-1,3-diazepine-2,4(3H)-dione 

Downstream Products

• 1562660-67-6 4-[6-methyl-5-(morpholin-4-ylcarbonyl)-2-oxo-4-phenyl-3,4-dihydropyrimidin-1(2H)-yl]butanoic acid 
• 1350618-28-8 isopropyl 4-(4,6-dimethyl-2-oxo-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-1-yl)-butanoate 
• 534-13-4 N,N-dimethylthiourea 
• 134-81-6 benzil 
• 1350618-34-6 1,3-diethyl-5,5-diphenyl-2-thioxoimidazolidin-4-one 
• 1350618-32-4 isopropyl 4-(4,6-diethyl-2-oxo-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-1-yl)butanoate 
• 105-55-5 N,N'-diethylthiourea 
• 1350618-22-2 methyl 4-(4,6-dimethyl-2-oxo-3a,6a-diphenyl-5-thioxooctahydroimidazo[4,5-d]imidazol-1-yl)butanoate 
• 123351-54-2 4,5-dimethoxy-1,3-dimethyl-4,5-diphenyltetrahydroimidazole-2-thione 
• 1266096-35-8 C₂₅H₃₀N₄O₄ 
• 1010820-70-8 C₃₇H₄₈BrN₅O₈ 
• 831217-44-8 C₁₈H₂₁BrN₂O₅ 
• 1010820-79-7 3-((3S)-3-(4-(4-(4-bromophenyl)-5-(ethoxycarbonyl)-6-methyl-2-oxo-3,4-dihydropyrimidin-1(2H)-yl)butanamido)-5-phenylpentanamido)propanoic acid 

Relevant academic research and scientific papers

Synthesis and Structure of 1-Substituted Semithioglycolurils

Two methods for the synthesis of previously unavailable 1-substituted semithioglycolurils were developed. These methods consist of the cyclocondensation of 1-substituted ureas with 4,5-dihydroxy- or 4,5-dimethoxyimidazolidine-2-thione or glyoxal, followed by the reaction of the resulting 1-substituted 4,5-dihydroxyimidazolidine-2-ones with HSCN in a two-step one-pot procedure. Two of the desired semithioglycolurils were obtained as conglomerates.

Chemical modulators of heat shock protein 70 (Hsp70) by sequential, microwave-accelerated reactions on solid phase

Molecular chaperones, such as Hsp70 and Hsp90, are responsible for a variety of protective, anti-apoptotic functions. While inhibitors of Hsp90, such as geldanamycin and its derivative 17-AAG, are well known and important anti-cancer leads, Hsp70 has rece

Synthesis of 2-monofunctionalized 2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7- diones

New (1R*,5S*)-2-R-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7- diones containing the terminal carboxy or hydroxy group in the substituent R were synthesized by cyclocondensation of 4,5-dihydroxyimidazolidin-2-one with 1-R-ureas. Single-crystal X-ray diffraction analysis showed that 2-carboxyethyl-2,4,6,8-tetraazabicyclo[3.3.0]octane-3,7-dione crystallizes as a racemate.

ISOLATION AND STRUCTURES OF NEW UREIDO AMINO ACIDS, LIVIDINE AND GRATELOUPINE, FROM RED ALGAE GRATELOUPIA C. AGARDH GENUS

Two new ureido amino acids, lividine (1) and grateloupine (2) , were isolated from Grateloupia livida and Grateloupia filicina respectively.The structures of both amino acids were assumed mainly by NMR spectra and determined as Nω-carbamoyl-L-c

1,3-Diazepinones. 2. The Correct Structure of Squamolone as 1-Carbamoyl-2-pyrrolidinone and Synthesis of Authentic Perhydro-1,3-diazepine-2,4-dione

The natural product squamolone,previously reported as 4-oxoperhydro-1,3-diazepin-2-one (1), was found to be instead 1-carbamoyl-2-pyrrolidinone (2).An unequivocal synthesis of the diazepinedione 1 starting from glutaric acid monoamide (6) produced the desired compound in five steps.Diborane reduction of 1 yielded the known perhydro-1,3-diazepin-2-one (10, tetramethyleneurea), confirming the seven-membered-ring structure of 1.A detailed analysis of the IR, NMR, and mass spectra of squamolone (2) and its isomer 1 is presented.A one-step synthesis of squamolone (2) starting with 4-aminobutyric acid 3 is reported.