75548-99-1

Usage

Class

Diazepines

Physical state at room temperature

White solid

Potential applications

Pharmaceutical research and drug discovery

Unique structure

Facilitates potential biological activity

Studied for

Chelating agent and development of new drugs

Target diseases

Various diseases (specific diseases not mentioned in the material)

Chemical structure

Versatile for applications in medicinal chemistry and drug development

Upstream product

• 84557-83-5 N,N'-Dichloropentandiamid 
• 75506-70-6 4-Isocyanato-butyramide 

Downstream Products

• 19055-93-7 1,3-diazepan-2-one 
• 2609-10-1 grateloupine 
• 40451-67-0 2-oxopyrrolidine-1-carboxamide 
• 107711-32-0 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4-(methylthio)tetrahydro-2H-1,3-diazepin-2-one 
• 107711-31-9 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)-4-thioxohexahydro-2H-1,3-diazepin-2-one 
• 107711-33-1 1-β-D-ribofuranosyl-4-aminotetrahydro-2H-1,3-diazepin-2-one 
• 107711-22-8 1-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrahydro-2H-1,3-diazepine-2,4(3H)-dione 
• 107711-25-1 3-(2,3,5-tri-O-benzoyl-β-D-ribofuranosyl)tetrahydro-2H-1,3-diazepine-2,4(3H)-dione 

Relevant academic research and scientific papers

1,3-Diazepinones. 2. The Correct Structure of Squamolone as 1-Carbamoyl-2-pyrrolidinone and Synthesis of Authentic Perhydro-1,3-diazepine-2,4-dione

The natural product squamolone,previously reported as 4-oxoperhydro-1,3-diazepin-2-one (1), was found to be instead 1-carbamoyl-2-pyrrolidinone (2).An unequivocal synthesis of the diazepinedione 1 starting from glutaric acid monoamide (6) produced the desired compound in five steps.Diborane reduction of 1 yielded the known perhydro-1,3-diazepin-2-one (10, tetramethyleneurea), confirming the seven-membered-ring structure of 1.A detailed analysis of the IR, NMR, and mass spectra of squamolone (2) and its isomer 1 is presented.A one-step synthesis of squamolone (2) starting with 4-aminobutyric acid 3 is reported.