26103-07-1

Basic information

• Product Name: Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether
• Synonyms: Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether;1,1,1,3,3,3-Hexafluoro-2-chloromethoxypropane;Chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether;Chloromethyl hexafluoroisopropyl ether;Ether chloromethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl;2-(Chloromethoxy)-1,1,1,3,3,3-hexafluoropropane;Chloromethyl-1,1,1,3,3,3-Hexafluoroisopr;1,1,1,3,3,3-Hexafluoroisopropyl chloromethyl ether
• CAS NO: 26103-07-1
• Molecular Formula: C₄H₃ClF₆O
• Molecular Weight: 216.5094392
• Mol File: 26103-07-1.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 95℃
• Flash Point: 11℃
• Appearance: /
• Density: 1.488
• Vapor Pressure: 52.835mmHg at 25°C
• Refractive Index: 1.31
• CAS DataBase Reference: Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether(CAS DataBase Reference)
• NIST Chemistry Reference: Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether(26103-07-1)
• EPA Substance Registry System: Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether(26103-07-1)

Safety Data

• Hazardous Substances Data: 26103-07-1(Hazardous Substances Data)

Usage

General Description

Chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether is a chemical compound that is often used as a solvent and reagent in various chemical reactions and processes. It is a fluorinated ether compound, containing carbon, hydrogen, chlorine, and fluorine atoms. This chemical is characterized by its highly fluorinated structure, which provides it with unique chemical and physical properties. It is commonly used as a solvent in organic synthesis, as well as in the production of various industrial chemicals and pharmaceuticals. Additionally, it can also be used as a reagent in the preparation of certain organic compounds, making it a valuable tool in organic chemistry research and development. However, it is important to handle and use this compound with caution, as it may pose risks to human health and the environment if not handled properly.

InChI:InChI=1/C4H3ClF6O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2

Upstream product

• 110-88-3 1,3,5-Trioxan 
• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 
• 50-00-0 formaldehyd 
• 194039-83-3 bis {[2,2,2-trifluoro-1-(trifluoromethyl)ethoxy]methyl} ether 
• 1016982-73-2 dihexafluoro isopropanol triformal 
• 28523-86-6 sevoflurane 
• 13171-18-1 1,1,1,3,3,3-hexafluoro-2-methoxypropane 

Downstream Products

• 920-66-1 1,1,1,3',3',3'-hexafluoro-propanol 
• 1357476-59-5 bis-1,3-(1,1,1,3,3,3-hexafluoroiso-propoxymethyl)imidazolium chloride 
• 1357476-58-4 1-(1,1,1,3,3,3-hexafluoroisopropoxy-methyl)-3-methylimidazolium chloride 
• 206756-25-4 2-Chloromethoxy-1,1,3,3,3-pentafluoro-propene 
• 28523-86-6 sevoflurane 

Relevant articles and documents

An efficient and environmentally friendly synthesis of the inhalation anesthetic sevoflurane

We report a new, high yield, single vessel synthesis of the general anesthetic sevoflurane. The new synthesis consists of a two-stage fluoromethylation of hexafluoroisopropanol. In the first stage, hexafluoroisopropanol is chloromethylated using aluminum trichloride and trioxane. In the second stage fluorine exchange is carried out using potassium fluoride and poly(ethylene glycol). Sevoflurane is distilled directly from the reaction vessel yielding material of 99.95% purity. The overall yield of the process is 65-70%.

Method for synthesizing sevoflurane intermediate

The invention discloses a method for synthesizing a sevoflurane intermediate. The method specifically comprises the processes that hexafluoroisopropanol, aluminum chloride anhydrous and paraformaldehyde are dissolved in acetonitrile and react in a homogeneous condition, and then through acidification by a hydrochloric acid solution, standing, separation and water washing, the sevoflurane intermediate chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether is obtained. The method for synthesizing the sevoflurane intermediate has the advantages that the acetonitrile is taken as a solvent to make thereaction system tend to be homogeneous, thereby solving the problem that stirring is difficult due to the conglomeration of viscous by-products during the reaction, so that the reaction is more complete; the acetonitrile can be removed through water washing, so that it is avoided that the organic solvent is removed through high temperature rectification, thereby avoiding the occurrence of side reactions in the high temperature rectification process, and improving the purity and yield of the reaction product chloromethyl-1,1,1,3,3,3-hexafluoroisopropyl ether; the reaction process is simple, nospecial equipment is required, and the method is suitable for industrial production.

Method for synthesizing chloromethy-1,1,1,3,3,3-hexafluoroisopropyl ether

The invention discloses a method for synthesizing chloromethy-1,1,1,3,3,3-hexafluoroisopropyl ether. The method includes the steps that 1, hexafluoroisopropanol and paraformaldehyde are added to a high-pressure reaction kettle, anhydrous aluminium trichloride is added to the high-pressure reaction kettle after even stirring, the temperature in the high-pressure reaction kettle is controlled to be 0-50 DEG C, then carbon dioxide gas is led to the kettle, heat-preservation stirring reaction is performed after gas leading is completed, and the adding amount of the carbon dioxide gas is used for making carbon dioxide in a liquid or supercritical state; 2, the carbon dioxide is discharged out, the reaction material is dissolved with hydrochloric acid, an organic layer is separated out and is washed with water to obtain the chloromethy-1,1,1,3,3,3-hexafluoroisopropyl ether. The method uses the liquid or supercritical carbon dioxide as a solvent to facilitate stirring and make the reaction performed completely, the carbon dioxide is easily separated from a product, the complicated post-treatment process is omitted, the yield of the product is 90% or above, and the purity is 98% or above.

Method for recycling sevoflurane impurity F(1)

The invention discloses a method for recycling a sevoflurane impurity F(1) in a sevoflurane coarse product to reduce the environment pollution. The method transforms a fluorine-containing effluent hard to degrade in the natural environment into a useful reagent, the environment pollution is reduced, the cost is lowered, and the clean production of sevoflurane is implemented.