26107-82-4

Basic information

• Product Name: 3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE
• Synonyms: 3,5-Bis(trifluoromethyl)benzohydrazide;Benzoic acid, 3,5-bis(trifluoromethyl)-, hydrazide;BUTTPARK 35\03-78;3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE;3,5-BIS(TRIFLUOROMETHYL)BENZOIC ACID HYDRAZIDE;3,5-DI(TRIFLUOROMETHYL)BENZHYDRAZIDE;3,5-DI(TRIFLUOROMETHYL)BENZOIC ACID HYDRAZIDE;3,5-DI(TRIFLUOROMETHYL)BENZENE-1-CARBOHYDRAZIDE
• CAS NO: 26107-82-4
• Molecular Formula: C₉H₆F₆N₂O
• Molecular Weight: 272.15
• EINECS: 247-462-1
• Mol File: 26107-82-4.mol
• Article Data: 9

Chemical Properties

• Melting Point: 131-135 °C
• Appearance: white crystalline powder
• Density: 1.479 g/cm³
• Refractive Index: 1.442
• PKA: 11.21±0.10(Predicted)
• BRN: 2596448
• CAS DataBase Reference: 3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE(26107-82-4)
• EPA Substance Registry System: 3,5-BIS(TRIFLUOROMETHYL)BENZHYDRAZIDE(26107-82-4)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 37/39-26
• HazardClass: IRRITANT
• Hazardous Substances Data: 26107-82-4(Hazardous Substances Data)

Usage

Chemical Properties

white crystalline powder

InChI:InChI=1/C9H6F6N2O/c10-8(11,12)5-1-4(7(18)17-16)2-6(3-5)9(13,14)15/h1-3H,16H2,(H,17,18)

Upstream product

• 96617-71-9 3,5-bis-trifluoromethylbenzoic acid ethyl ester 
• 26107-80-2 3’,5’-bis(trifluoromethyl)acetophenone 
• 785-56-8 3,5-bis(trifluoromethyl)phenyl carboxylic acid chloride 
• 725-89-3 3,5-bistrifluoromethylbenzoic acid 

Downstream Products

• 1219921-87-5 C₁₄H₁₂F₆N₂O₄ 
• 1221887-42-8 1-[3,5-bis(trifluoromethyl)benzoyl]-2-(4-methoxycarbonylbenzoyl)hydrazine 
• 220381-26-0 5-(3,5-bis(trifluoromethyl)phenyl)-1,3,4-oxadiazol-2(3H)-one 

Relevant articles and documents

Design, Synthesis, and Study of the Insecticidal Activity of Novel Steroidal 1,3,4-Oxadiazoles

A series of novel steroidal derivatives with a substituted 1,3,4-oxadiazole structure was designed and synthesized, and the target compounds were evaluated for their insecticidal activity against five aphid species. Most of the tested compounds exhibited potent insecticidal activity against Eriosoma lanigerum (Hausmann), Myzus persicae, and Aphis citricola. Compounds 20g and 24g displayed the highest activity against E. lanigerum, showing LC50 values of 27.6 and 30.4 μg/mL, respectively. Ultrastructural changes in the midgut cells of E. lanigerum were detected by transmission electron microscopy, indicating that these steroidal oxazole derivatives might exert their insecticidal activity by destroying the mitochondria and nuclear membranes in insect midgut cells. Furthermore, a field trial showed that compound 20g exhibited effects similar to those of the positive controls chlorpyrifos and thiamethoxam against E. lanigerum, reaching a control rate of 89.5% at a dose of 200 μg/mL after 21 days. We also investigated the hydrolysis and metabolism of the target compounds in E. lanigerum by assaying the activities of three insecticide-detoxifying enzymes. Compound 20g at 50 μg/mL exhibited inhibitory action on carboxylesterase similar to the known inhibitor triphenyl phosphate. The above results demonstrate the potential of these steroidal oxazole derivatives to be developed as novel pesticides.

AMINO ALCOHOL DERIVATIVE, PHARMACEUTICAL COMPOSITION AND APPLICATION THEREOF

The present invention belongs to the field of medicine, and specifically discloses an amino alcohol derivative represented by Formula I, a pharmaceutically acceptable salt, solvate, polymorph or prodrug thereof. In addition, the present invention also discloses a pharmaceutical composition comprising the above substances, and a use of the substance in the preparation of a medicament for the prevention and treatment of an immune inflammatory disease, or a disease or condition associated with immunological competence such as multiple sclerosis, ALS, CIDP, systemic lupus erythematosus, rheumatoid arthritis, ulcerative colitis, psoriasis, polymyositis, etc.

A general and efficient entry to asymmetric tetrazines for click chemistry applications

The importance of click chemistry is widely recognized. Among all the known click reactions, those involving tetrazines represent the fastest click reactions reported and are generating a great deal of interest. However, there is no efficient entry to asymmetric tetrazines and those with strong electron withdrawing groups, which limits the development of this field. Herein, we report a general and efficient entry to asymmetric tetrazines with strongly electron withdrawing groups.